PHARMACOKINETICS: NEONATES AND INFANTS Flashcards
• In neonates and young infants, drug responses may be unusually _____and _____.
Intense
Prolonged
• Because of organ system _____, very young patients are highly sensitive to drugs.
Immaturity
• Absorption of _____drugs in NEONATES is slower than in adults.
IM
Absorption of _____drugs in INFANTS is more rapid than in adults.
IM
absorption of IM drugs in INFANTS is more _____ than in adults.
Rapid
• Absorption of IM drugs in
NEONATES is _____than in adults.
Slower
In early life, free concentrations of some drugs may be especially high due to limited _____ ______ _____.
Protein binding capacity
neonates are especially sensitive to drugs that affect the central nervous system (CNS).
This is because the _____ _____ _____ is not fully developed.
Central nervous system
Blood brain barrier
The drug-metabolizing capacity of neonates is _____. Hence, neonates are especially sensitive to drugs that are eliminated primarily by _____ metabolism.
Low
Hepatic
Renal excretion of drugs is _____in neonates. Hence, drugs that are eliminated primarily by the _____must be given in reduced dosage.
Low
Kidney
In neonates, drugs excreted by the kidneys must be given in _____.
Reduced dosages
considered at high risk for adverse effects from drugs due to to organ immaturity.
Infants
reduces the metabolism and excretion of drugs in infants.
organ immaturity
causes drugs to pass more readily into the central nervous system.
blood-brain barrier
can impact drug absorption in infants when administered orally.
variable peristalsis
