CYP 450, GRAPEFRUIT, and You! Flashcards
1
Q
Most responsible for the drug metabolism reaction and affect
A
CYP 450
cytochrome P 450
2
Q
Many drugs use the Cytochrome P450 enzyme system for _____.
A
metabolism
3
Q
Grapefruit juice is a food that inhibits the metabolism of drugs through the_____.
A
CP450 system.
4
Q
Only one grapefruit or _____ _____ of juice may cause a clinically significant drug reaction.
A
one cup
5
Q
Only one grapefruit or one cup of juice may cause a clinically significant drug reaction as it permanently inactivates _____ enzymes in the gut.
A
CYP3A4
6
Q
This effect ON CYP3A4 lasts for up to _____ hours.
A
72 HOURS
7
Q
Drug levels of any drug that is metabolized by the CYP3A4 system will _____ due to this interaction. .
A
rise
