ELDERLY...PHARMACOKINETIC CHANGES IN THE ELDERLY

Question 0

Individualization of therapy for the elderly is essential: Each patient must be monitored for _____and _____ _____, and the regimen must be adjusted accordingly.

Answer 0

Desired

Adverse responses

Question 1

Older patients are generally more _____to drugs than are younger adults, and they show wider individual _____.

Answer 1

Sensitive

Variation

Question 2

Therapy for the elderly must be ______.

Answer 2

Individualized

Question 3

Aging-related _____ _____can change drug absorption, distribution, metabolism, and (especially) excretion.

Answer 3

Organ decline

Question 4

Aging-related organ decline can change ….

Answer 4

drug absorption,
distribution,
metabolism,
and (especially) excretion.

Question 5

The rate of drug absorption may be _____ in the elderly,

although the extent of absorption is usually _____.

Answer 5

Slowed

Unchanged

Question 6

Plasma concentrations of lipid-soluble drugs may be _____in the elderly.

Answer 6

Low

Question 7

Concentrations of water-soluble drugs may be _____ in the elderly.

Answer 7

High

Question 8

• Reduced liver function may _____drug effects in the elderly.

Answer 8

Prolong

Question 9

• Reduced renal function, with resultant drug accumulation, is the most important cause of _____ _____ _____ in the elderly.

Answer 9

Adverse drug reactions

Question 10

The most important cause of adverse drug reactions in the elderly is …..

Answer 10

• Reduced renal function

Leading to drug accumulation,

Question 11

Because the degree of renal impairment among the elderly, _____ _____ should be determined for all patients taking drugs that are eliminated primarily by the kidneys.

Answer 11

Creatinine clearance