Pharmacodynamics-drug-receptor interactions

Question 1

Any functional macro molecule in a cell to which a drug binds to produce its effects

Answer 1

The receptor

Question 2

Binding of drugs to their receptors is almost always

Answer 2

Reversible

Question 3

Under physiological conditions, receptor function is regulated by_____supplied by the body.

Answer 3

Molecules

Question 4

All the drugs can do at receptors is_____ or_____the action of the body’s own regulatory molecules.

Answer 4

Mimic

Block

Question 5

Makes selective drug action possible

Answer 5

Receptors

Question 6

Drugs cannot give cells new____

Answer 6

Functions

Question 7

Drugs can only alter the rate of preexisting

Answer 7

Processes

Question 8

Name the four primary families of receptors

Answer 8

gated ion channels
Transmembranous receptors
G protein-coupled receptors
Intracellular receptors

Question 9

Selectivity does not guarantee

Answer 9

Safety

Question 10

If a drug interacts with multiple receptors Its effects will be

Answer 10

Nonselective

Question 11

If a drug interacts with only one type of receptor, but that receptor type regulates multiple processes, Then the effects of the drug will be

Answer 11

Nonselective

Question 12

If the drug interactions only one type of receptor, and if that receptive type regulates just a few processes, and the effects of the drug will be relatively

Answer 12

Selective

Question 13

refers to the strength of the attraction between a drug and its receptor.

Answer 13

Affinity

Question 14

• Drugs with high affinity have high relative _____.

Answer 14

potency.

Question 15

refers to the ability of a drug to activate receptors.

Answer 15

Intrinsic activity

Question 16

• Drugs with high intrinsic activity have high maximal _____.

Answer 16

efficacy.

Question 17

molecules that activate receptors.

Answer 17

Agonists

Question 18

drugs that prevent receptor activation by endogenous regulatory molecules and by other drugs.

Answer 18

Antagonists

Question 19

allows the antagonist to bind to receptors, but lack of intrinsic activity prevents the bound antagonist from causing receptor activation.

Answer 19

Affinity

Question 20

have no observable effects in the absence of agonists.

Answer 20

Antagonists

Question 21

have only moderate intrinsic activity. Hence their maximal efficacy is lower than that of full agonists.

Answer 21

Partial agonists

Question 22

can act as agonists (if there is no full agonist present) and as antagonists (if a full agonist is present).

Answer 22

Partial agonists