DRUG THERAPY DURING PREGNANCY: TERATOGENESIS

Question 0

• About _____ of all babies are born with gross structural malformations.

Ooo

Answer 0

3%

Question 1

• When prescribing drugs during pregnancy, the clinician must try to balance the _____of treatment versus the ____ -often without knowing what the _____really are.

Xxx

Answer 1

Benefits
Risk
Risk

Question 2

• Less than _____of birth defects are caused by drugs.

Ooo

Answer 2

1%

Question 3

-_____-_____gross malformations result from exposure early in pregnancy (weeks 4 through 8 of gestation), the time of _____.

Xxx

Answer 3

Teratogen-induced

Organogenesis

Question 4

_____ _____ (eg, mental retardation) result from exposure to teratogens later in pregnancy.

Xxx

Answer 4

Functional impairments

Question 5

• For most drugs, we lack _____ _____ on the risks of use during pregnancy.

Xxx

Answer 5

Reliable data

Question 6

• Lack of teratogenicity in animals is not proof of _____in humans.

Xxx

Answer 6

Safety

Question 7

• Some drugs (eg, thalidomide) cause birth defects with just -_____ _____whereas others (eg, alcohol) require _____ _____.

Ooo

Answer 7

One dose

Prolonged exposure

Question 8

FDA Pregnancy Risk Categories indicate the _____ _____of drug use.

ooo

Answer 8

Relative risks

Question 9

Drugs in Category _____pose the highest risk of fetal harm and are contraindicated during pregnancy.

Xxx

Answer 9

X

Question 10

Any woman of reproductive age who is taking a known _____must be counseled about the _____ _____and the necessity of using at least one reliable form of birth control.

Ooo

Answer 10

Teratogen

Teratogenic risk