Tissue Plasminogen Activator Flashcards
1
Q
what is it and mechanism
A
thrombolytic drug
binds to blood clots and breaks down the fibrin matrix
2
Q
indications
A
acute MI
massive PE with haemodynamic instability
Acute Ischaemic Stroke if given in 4 hours
3
Q
contraindications
A
acute pancreatitis
aneurysm
recent surgery
oral anticoagulants e.g. warfarin (high INR)
severe liver disease
4
Q
interactions
A
anticoagulants e.g. LMWH (e.g. Enoxaparin)
ACE inhibitors
5
Q
side effects
A
intracerebral haemorrhage
angina
hypotension
heart failure and associated pulmonary oedema
