Spironolactone Flashcards
1
Q
What is it and mechanism
A
aldosterone receptor antagonist
potassium sparing diuretic
competitively inhibits mineralocorticoid receptors in DCT to promote Na and water excretion and potassium retention
note that these channels are dependant on aldosterone
2
Q
indications
A
oedema especially in congestive heart failure
ascites in cirrhosis of the liver
nephrotic syndrome
3
Q
contraindications
A
Addison’s disease (too little cortisol production in the adrenal glands)
anuria
hyperkalaemia
4
Q
interactions
A
Abiaterone (advanced prostate cancer treatment)
Mitotane (Cushing’s and adrenocortical carcinoma treatment)
5
Q
Side effects
A
drowsiness
dizziness
d and v
can be
AKI
muscle spasms
