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Cardiovascular Drugs > Simvastatin > Flashcards

Simvastatin Flashcards

1
Q

what is it and mechanism

A

Statin

It inhibits HMG Co-A reductase, an enzyme in the cholesterol synthesis pathway

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2
Q

indications

A

Hypercholesterolaemia

prevention of an atherosclerotic event in people with risk factors

secondary prevention of an MI

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3
Q

contraindications

A

acute liver disease (high AST/ALT)

pregnancy/ lactation

rhabdomyolysis/ myopathy

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4
Q

interactions

A

Amiodarone

amlodipine

antifungals/ clarithromycin/ erythromycin

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5
Q

side effects

A

all side effects are frare

Asthenia (loss of strength)- muscle weakness

constipation

skin conditions e.g. rash, pruritus

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Cardiovascular Drugs (17 decks)

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