Isosorbide Mononitrate Flashcards
1
Q
What is it and mechanism
A
Nitrate
stimulates guanylyl cyclase and subsequently cGMP conc in cells causing vascular smooth muscle relaxation
vasodilator
2
Q
indications
A
Prophylaxis of angina
heart failure
generally less preferred than beta blockers e.g. Atenolol
3
Q
contraindications
A
aortic stenosis cardiac tamponade hypotension hypovolaemia anaemia raised intracranial pressure
4
Q
interactions
A
Erectile dysfunction drugs e.g. Avanafil, tadalafil, vardenafil,
Dapsone (for leprosy and dermatitis herpetiformis)
Prilocaine (local anaesthetic)
5
Q
side effects
A
arrhythmia
dizziness/ drowsiness/ headache
hypotension
nausea and vomiting
