Bendroflumethiazide

Question 1

what is it and mechanism

Answer 1

thiazide diuretic

inhibits Na and Cl reabsorption in the DCT (as opposed to LofH in loop) leading to more excretion of water

used more in the treatment of hypertension than loops

Question 2

indications

Answer 2

hypertension

oedema caused by heart failure

Question 3

contraindications

Answer 3

Addison’s disease (adrenal gland doesn’t produce too little cortisol)

hypercalcaemia

hyponatraemia

hypokalaemia

Question 4

interactions

Answer 4

anti-arrhythmias e.g. amiodarone, digoxin

NSAIDS e.g. aspirin, ibuprofen, naproxen

calcium carbonate, chloride etc.

SSRI e.g.citalopram

macrolide antibiotics e.g. clarithromycin, erythromycin

targeted cancer cells e.g. sunitinib

antifungals e.g. fluconazole

Question 5

side effects

Answer 5

thirsty, dry mouth
nausea
d and v
constipation
stomach pain
loss of appetite
unexpected weight loss