Thyroid and breast Flashcards
Histological finding for Papillary carcinoma
Psammoma bodies and orphan Annie nuclei
What is the metastatic spread of papillary carcinoma?
Lymphatic spread
Macroscopic finding of Follicular carcinoma
Well encapsulated invasion on microscopic evaluation
What is the metastatic spread of follicular carcinoma?
Haematogenous spread (can include bone)
Who is anaplastic carcinoma most commonly seen in
Elderly females
Which cells of origin is medullary carcinoma
Parafollicular (C Cells) - of the thyroid
In medullary carcinoma what is serum calcitonin?
Elevated
Metastatic spread of medullary carcinoma?
Both lymph and haematogenous
Which malignancy are you risk of developing with autoimmune thyroiditis
Thyroid lymphoma
Which thyroid cancer is associated with phaeochromocytoma?
medullary thyroid cancer
Which is the most common subtype of thyroid cancer?
Papillary carcinoma
Which thyroid cancer is included in MENIIa and IIb?
Medullary thyroid cancer
Which blood test is useful to screen for papillary carcinoma recurrence?
Thyroglobulin levels
What is berry sign?
Absence of carotid pulse due to malignant thyromegally
What is CD20 a marker for?
B cell lymphoma (thyroid)
What is seen histologically in lymphoma?
dense lymphatic tissue
Lymphocytic infiltrates and fibrosis are seen in which disease?
hashimotos thyroiditis
What makes up psammoma bodies seen in papillary lesions?
Dystrophic calcification
What makes up a fibroadenoma?
Stromal and epithelial components
Which medication is used in breast cancer for oestrogen sensitive breast cancer?
Tamoxifen pre menopausal, letrozole post menopausal
which immunoglobulin is involved in graves?
IgG
Which antibodies are involved in hashimotos thyroiditis?
antithyroglobulin and anti microsomal antibodies
What is produced by the anterior pituitary?
GH, ACTH, TSH, FSH and LH
What is produced by the posterior pituitary?
ADH and oxytocin
What is a rapidly growing breast tumour?
Phyllodes tumour