Thrombolytics/fibrinolytic agents

Question 1

What is the treatment for Streptokinase and Urokinase toxicity?

Answer 1

Aminocaproic Acid

Question 2

______________ is a bacterial protein that complexes with plasminogen, thereby activating it.

Answer 2

Streptokinase

Question 3

What is the MOA of streptokinase?

Answer 3

complexes with plasminogen and converting it to plasmin

Question 4

The MOA of Reteplase is to _____

Answer 4

activate plasminogen into plasmin

Question 5

What is the fibrin specificity of Streptokinase?

Answer 5

Minimal

Question 6

What is the fibrin specificity of Reteplase?

Answer 6

Moderate

Question 7

Reteplase (rPA) and Tenecteplase (TNK-tPA) are (drug class)_________

Answer 7

thrombolytics; tissue plasminogen activator

Question 8

What is the fibrin specificity of Tenecteplase?

Answer 8

High

Question 9

MOA of Reteplase and tenecteplase

Answer 9

activation/conversion of plasminogen to plasmin, which then cleaves thrombin and fibrin clots.

*plasmin breaks down fibrin that holds the clot together

Question 10

Increased tissue plasminogen activator leads to _________ of clotting factors, _______ of fibrin formation, _______ of plasminogen and __________ of platelet aggregation.

Answer 10

destruction of clotting factors and cleavage of fibrin formation, cleavage of plasminogen and blockage of platelet aggregation.

Question 10

What activates plasminogen by converting it into plasmin?

Answer 10

Tissue plasminogen activator

Question 11

Increased tissue plasminogen activator leads to?

Answer 11

increased bleeding time
increased prothrombin time
increased partial thromboplastin time
unchanged platelet count