drugs for dyslipidaemias

Question 1

What is the musculoskeletal toxicity of fibrates?

Answer 1

myopathy

Question 2

What is the MOA of gemfibrozil (fibrates)?

Answer 2

Activation of PPAR-alpha; thereby yielding increased lipoprotein lipase expression

Question 3

What type of antihyperlidemic is clofibrate?

Answer 3

fibrate

Question 4

What type of antihyperlipidemic yields the greatest decrease in triglycerides?

Answer 4

fibrates

Question 5

_____________is a musculoskeletal adverse effect of fibrates that has an increased risk of occuring when given with statins.

Answer 5

myositis

Question 6

_____________ is an adverse effect of fibrates that is characterized by increased liver function tests (LFTs).

Answer 6

Hepatotoxicity

Question 7

___________________ are a biliary adverse effect of fibrates, especially when given concurrently with bile acid resins.

Answer 7

Cholesterol gallstones

Question 8

What is the common suffix for HMG-CoA reductase inhbitors?

Answer 8

-statin

Question 9

What is the MOA of Lovastatin (statins)?

Answer 9

Competitive inhibition of HMG-CoA Reductase

Question 10

What is the pregnancy category of Lovastatin?

Answer 10

X

Question 11

What type of antihyperlipidemics are lovastatin, pravastatin, atorvastatin and simvastatin?

Answer 11

HMG-CoA Reductase Inhibitor

Question 12

What type of antihyperlipidemic is Cholestyramine?

Answer 12

Bile acid resin/ bile acid sequestrants

Question 13

What is the MOA of chloestyramine?

Answer 13

inhibit bile acid reabsorption at terminal ileum, thereby the liver has to use cholesterol to make more

Question 14

Mechanism of action of statin

Answer 14

inhibition of HMG CoA reductase enzyme

Question 15

Mechanism of action of fibrates

Answer 15

Activation of nuclear transcription receptor PPAR-alpha

Question 16

Mechanism of action of ezetimibe

Answer 16

Inhibition of intestinal absorption of cholesterol and phytosterols

Question 17

MOA of cholestyramine

Answer 17

Inhibition of bile acid reabsorption

Question 18

MOA of niacin

Answer 18

Inhibition of hormone-sensitive lipase enzyme in adipose tissue

Question 19

A drug which is useful for low HDL states but limits due to adverse effects

Answer 19

niacin

Question 20

What is the role of PCSK-9 in our body?

Answer 20

enhancing lysosomal degradation of LDL receptor

Question 21

I am taking statin and fibrate together, which adverse effect is most likely to encounter?

Answer 21

rhabdomyolysis

Question 22

which is the drug of choice for a high LDL?

Answer 22

atorvastatin

Question 23

Which is the best drug for hypertriglyceridaemia?

Answer 23

clofibrate

Question 24

Which is the best recommendable drug for low HDL?

Answer 24

niacin