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CRP 1 KCP 1 & 2 > drugs for dyslipidaemias > Flashcards

drugs for dyslipidaemias Flashcards

1
Q

What is the musculoskeletal toxicity of fibrates?

A

myopathy

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2
Q

What is the MOA of gemfibrozil (fibrates)?

A

Activation of PPAR-alpha; thereby yielding increased lipoprotein lipase expression

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3
Q

What type of antihyperlidemic is clofibrate?

A

fibrate

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4
Q

What type of antihyperlipidemic yields the greatest decrease in triglycerides?

A

fibrates

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5
Q

_____________is a musculoskeletal adverse effect of fibrates that has an increased risk of occuring when given with statins.

A

myositis

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6
Q

_____________ is an adverse effect of fibrates that is characterized by increased liver function tests (LFTs).

A

Hepatotoxicity

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7
Q

___________________ are a biliary adverse effect of fibrates, especially when given concurrently with bile acid resins.

A

Cholesterol gallstones

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8
Q

What is the common suffix for HMG-CoA reductase inhbitors?

A

-statin

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9
Q

What is the MOA of Lovastatin (statins)?

A

Competitive inhibition of HMG-CoA Reductase

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10
Q

What is the pregnancy category of Lovastatin?

A

X

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11
Q

What type of antihyperlipidemics are lovastatin, pravastatin, atorvastatin and simvastatin?

A

HMG-CoA Reductase Inhibitor

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12
Q

What type of antihyperlipidemic is Cholestyramine?

A

Bile acid resin/ bile acid sequestrants

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13
Q

What is the MOA of chloestyramine?

A

inhibit bile acid reabsorption at terminal ileum, thereby the liver has to use cholesterol to make more

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14
Q

Mechanism of action of statin

A

inhibition of HMG CoA reductase enzyme

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15
Q

Mechanism of action of fibrates

A

Activation of nuclear transcription receptor PPAR-alpha

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16
Q

Mechanism of action of ezetimibe

A

Inhibition of intestinal absorption of cholesterol and phytosterols

17
Q

MOA of cholestyramine

A

Inhibition of bile acid reabsorption

18
Q

MOA of niacin

A

Inhibition of hormone-sensitive lipase enzyme in adipose tissue

19
Q

A drug which is useful for low HDL states but limits due to adverse effects

20
Q

What is the role of PCSK-9 in our body?

A

enhancing lysosomal degradation of LDL receptor

21
Q

I am taking statin and fibrate together, which adverse effect is most likely to encounter?

A

rhabdomyolysis

22
Q

which is the drug of choice for a high LDL?

A

atorvastatin

23
Q

Which is the best drug for hypertriglyceridaemia?

A

clofibrate

24
Q

Which is the best recommendable drug for low HDL?

CRP 1 KCP 1 & 2 (16 decks)

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