antiarrhythmias class I: Na channel blockers

Question 1

Procainamide is a class ____ antiarrhythmic drug.

Answer 1

IA

Question 2

______________________ syndrome is an autoimmune-like complication of procainamide use.

Answer 2

Systemic lupus erythematosus-like

Question 3

What is the main mechanism of quinidine action as an anti-arrhythmic?

Answer 3

blockade of activated Na channels

Question 4

What is the effect of quinidine on the QT interval?

Answer 4

prolongation

Question 5

What is the effect of quinidine on the automaticity of cardiomyoctyes?

Answer 5

decrease

Question 6

What is an adverse effect of quinidine administration and is characterised by autonomic nervous system dysfunction?

Answer 6

cinchonism
It is an adverse effect of quinidine due to its ability to act as both an anti-muscarinic and alpha blocker.

Question 7

Quinidine is contraindicated in patients with prolonged _____ intervals.

Answer 7

QT

Question 8

__________ is used as an antidote for quinidine toxicity because it helps to reverse the cardiotoxic electrocardiographic effects.

Answer 8

Sodium lactate

Question 9

Procainamide is an antiarrhythmic that causes an (increase/ decrease) in cardiac action potential duration, thus slowing the heart rate.

Answer 9

increase

Question 10

Procainamide (increases/ decreases) the slope of phase 0 depolarization of the cardiac action potential.

Answer 10

decreases

Question 11

What is the main MOA of flecainide?

Answer 11

blocks activated Na channels

Question 12

The systemic lupus erythematosus-like syndrome caused by procainamide can be diagnosed by finding _______antibodies in the serum.

Answer 12

anti-histone

Question 13

Class IA antiarrhythmics like procainamide block _____ channels in heart.

Answer 13

sodium

Question 14

Class _____ sodium channel blocks are contraindicated in structural and ischemic heart disease.

Answer 14

Ic

Question 15

Procainamide (shortens/ prolongs) the effective refractory period of cardiac myocytes to cause its effect.

Answer 15

prolongs

Question 16

What class of antiarrhythmic is quinidine?

Answer 16

Class IA

Question 17

The systemic lupus erythematosus-like syndrome casued by procainamide is (reversible/ irreversible) .

Answer 17

reversible

Question 18

What class of antiarrhythmic is disopyramide?

Answer 18

Class IA

Question 19

______________ is an adverse effect of quinidine that involves headache and tinnitus.

Answer 19

Cinchonism

Question 20

Procainamide causes state (dependent/independent) suppression of HR.

Answer 20

dependent

Question 21

______________ is a class IA antiarrhythmic that is associated with HF as an adverse effect.

Answer 21

disopyramide

Question 22

List the class of antiarrhythmics.

Mexiletine
Flecainide
Propafenone

Answer 22

Mexiletine- Class IB
Flecainide & Propafenone- Class IC

Question 23

____________________ is a procainamide-induced arrhythmia that can occur from the drug’s effect of prolonging the QT interval.

Answer 23

Torsades de pointes

Question 24

_____________________ is the drug of choice for treating Wolff-Parkinson-White syndrome.

Answer 24

Procainamide