Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

IHO week 6 and Final > Thrombolytics, Anticoagulants, and anti-platelet drugs > Flashcards

Thrombolytics, Anticoagulants, and anti-platelet drugs Flashcards

1
Q

ADP analogs (ADP receptor antagonists)

irreversible

use in pts that don’t tolerate ASA

A

Clopidogrel

Ticlopidine

Prasugrel

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

GP IIb/IIIa inhibitors

A

Abciximab

Eptifibatide

Tirofiban

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Thromboxane inhibitor

A

aspirin

acetylsalicylate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Adverse effect:

Thrombocytic Thrombocytopenic Purpura

A

ticlopidine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

ADP analog, activated by CYP2C19

A

Clopidogrel

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Humanized MAB against GP IIb/IIIa

A

Abciximab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Fibrinogen analog

A

Eptifibatide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

non-peptide competitive inhibitor of GP IIb/IIIa receptor

A

Tirofiban

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Inhibit final common pathway for platelet aggregation

  • angioplasty
  • acute coronary syndromes
A

GP IIb/IIIa receptor inhibitors

**given IV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Phophodiesterase 3 inhibitor

increases cAMP

vasodilator

needs to by given with ASA or warfarin

A

Dipyridamole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Indirect Thrombin Inhibitors

A

Unfractionated Heparin

LMW Heparin (Lovenox)

Fondaparinux (a pentasaccharide)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Direct Thrombin Inhibitors

A

Bivalirudin

Argatroban

Dabigatran (oral)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Binds to ATIII

knocks out Thrombin AND Xa

A

HMW heparin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

binds ATIII, more effect on Xa

A

LMW heparin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Only inhibits Xa with ATIII

100% bioavailability

A

Fondaparinux

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Antidote to HMW heparin OD…

A

Protamine

17
Q

Block synthesis of vit K dependent clotting factors

A

warfarin

18
Q

Direct factor Xa inhibitors

A

Rivaroxaban (xarelto)

Apixaban

Edoxaban

**no antidote

**don’t require monitoring

19
Q

Vit K dependent factors:

A 
II
VII
IX
X
protein C
20
Q

More active enantiomer of warfarin:

A

S

21
Q

metabolism of S enantiomer of warfarin:

A

CYP2C9

22
Q

Three tPAs:

A

altePLASE
retePLASE
tenectePLASE

23
Q

How do tPAs localized?

A

Preferentially activate plasminogen that is bound to fibrin

24
Q

Potent inhibitor of fibrinolysis

A

Aminocaproic acid

25
Q

Two older fibrinolytics

A

streptokinase
-facilitates formation of plasmin

urokinase

  • kidney enzyme
  • directly converts plasminogen to plasmin

IHO week 6 and Final (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions