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IHO week 6 and Final > Block 4 highish yield > Flashcards

Block 4 highish yield Flashcards

1
Q

Don’t let the sun set on…

A

AML M3

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2
Q

Most common leukemia in adults

A

CLL

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3
Q

CLL

mutated Ig Vh genes

A

better prog

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4
Q

Elevated B2 microglobulin

soluble CD23

CD38+

ZAP-70+

A

poor prog in CLL

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5
Q

13q-

A

best prog in CLL

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6
Q

17p-

A

worst prog in CLL

acts like mantle cell

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7
Q

CD38+

A

unmutated Ig genes = poorer prog CLL

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8
Q

NIGHT SWEATS

A

CLL

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9
Q

CTLA-4

A

binds B7

prevents runaway T-cell activity

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10
Q

Location of MHC I synthesis

A

RER

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11
Q

TAP 1 and 2

A

gets antigen into RER for upload on MHC I

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12
Q

ERAAP

A

inside RER

helps load antigen onto MHC I

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13
Q

Location of antigen loading onto MHC II

A

late endosome

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14
Q

“place holder” on MHC II

A

invariant chain

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15
Q

part of digested invariant chain left in MHC II

A

CLIP

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16
Q

replaces CLIP with antigen on MHC II

A

HLA-DM

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17
Q

inhibits HLA-DM

A

HLA-DO

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18
Q

location of invariant chain loading onto MHC II

A

RER

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19
Q

licenses DCs to cross present

A

CD40–CD40L

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20
Q

CD40 on what cell

A

DC

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21
Q

CD40L on what cells

A

Th’s

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22
Q

MHC II expression stimulated by

A

INF-y

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23
Q

TdT alone

A

early pro-B cell

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24
Q

TdT and CD45R

A

intermediate pro-B-cell

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25
Q

CD45R

downregulated TdT

A

Late pro-B cell

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26
Q

receptor for B cell growth and differentiation

A

CD45R

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27
Q

pro-B cell, chain recombination?

A

H-chain

DJ–VDJ

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28
Q

pre-B cell, chain recombination?

A

L-chain

V-J

**small pre-B cell

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29
Q

cytokine for B cell division and differentiation

A

IL-7

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30
Q

Btk

A

Bruton’s tyrosine kinase

XLA

no/few B-cells

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31
Q

reduced serum IgG, memory B cells

A

CVID

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32
Q

Prototypical TI-1 antigen

T cell independent

A

LPS

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33
Q

TI-2 antigen

A

large polysaccharides

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34
Q

TLR4 TI 1 B cell activation

A

polyclonal

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35
Q

BCR TI 1 B cell activation

A

clonal

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36
Q

B1 B cells bind type 2 TI antigens via…

A

cross-linking of BCR

clonal

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37
Q

“handcuffs” T-cell to APC —> too many Th1’s!

A

superantigen

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38
Q

CTL-Ps activated by..

A

licensed APCs

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39
Q

APCs licensed by…

A

Th1

Th17

PAMP+TLR

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40
Q

CTL-P activation molecules (4)

A

TCR–MHC I

CD28–CD80/86

41
Q

no IL-2 or CD25(IL-2R)

high L-selectin and CCR7

low CD44 and LFA-1

A

naive CTL-P

42
Q

CTL-P homing and retention in the lymph node

A

CCR7

43
Q

CTL Effector homing and retention at sites of inflammation

A

CD44 and LFA-1

44
Q

LFA-1

A

on CTL

binds ICAMs on target cell

45
Q

most effective NKs at killing target cells

A

CD56 low

46
Q

NK activity stimulated by:

A 
INF-a
INF-B
INF-y
TNF-a
IL-15
47
Q

CD16

A

NKs

recognizes IgG

48
Q

only inhibitory NK lectin-like receptor

A

CD94 aka NKG2A

**trumps everything

49
Q

only activating NK immunoglobulin-like receptor

A

KIR2DS1

50
Q

activation of NK cell

A

must bump into inhibitory signal at least once

51
Q

CMD

neutrophils

A

CML

52
Q

CMD

RBCs

A

Polycythemia vera

53
Q

CMD

platelets

A

Essential thrombocythemia

54
Q

CMD

everything

A

Myelofibrosis

55
Q

Basophilia

A

CML

56
Q

Philadelphia

A

CML

57
Q

Jak-2 mutation

A

Polycythemia vera

58
Q

Plethora (flushing)

A

Polycythemia vera

59
Q

high platelet count in YOUNG WOMEN

A

Essential thrombocythemia

60
Q

Massive extramedullary hematopoiesis

Teardrop red cells

A

Chronic myelofibrosis

61
Q

t(9;22)

A

CML

62
Q

BCR-ABL

A

CML

63
Q

auto inhibitor of ABL1

A

Myristate

64
Q

added from BCR

creates new binding site for intracellular signalling

A

Tyrosine-177

65
Q

specific ABL kinase inhibitor

A

Imantinib

66
Q

monoclonal plasma cell proliferation

osteolytic lesions

A

Multiple myeloma

67
Q

Bence-Jones proteins

A

Multiple myeloma

68
Q

stacking of RBCs like coins

A

rouleaux

multiple myeloma

69
Q

amyloid in marrow from light chain aggregates

A

multiple myeloma

70
Q

Plasma cell tumor

IgM

A

Waldenstrom macroglobulinemia

71
Q

classic triad for MM:

A

anemia

bone pain

renal failure

72
Q

CD5+ B cells

A

CLL

73
Q

bcl-2 rearrangment

A

CLL

74
Q

Splenomegaly without lymphadenopathy

TRAP+

A

Hairy Cell Leukemia

75
Q

CD25+

CD11c+

CD5-

A

Hairy Cell Leukemia

76
Q

T-cell CLL

neutropenia

A

Large Granulated Lymphocytic Leukemia

77
Q

Tingible body macrophages

A

Follicular hyperplasia

78
Q

Partial effacement

T-cell response to immune stimulus

A

Interfollicular hyperplasia

79
Q

Lymphoma

same as CLL

A

Small Lymphocytic Lymphoma

80
Q

t(11;14)

A

Mantle Cell Lymphoma

81
Q

t(14;18)

A

Follicular Lymphoma

82
Q

“butt cells”

A

Follicular Lymphoma

83
Q

Cerebriform lymphocytes

Skin lesions

T-cell

A

Mycosis Fungoides

84
Q

Large mitotically active B cells

A

Diffuse Large Cell Lymphoma

85
Q

Lymphoma same as ALL

A

Lymphoblastic

86
Q

Teenage male with mediastinal mass

A

Lymphoblastic lymphoma

87
Q

Starry-sky

A

Burkitt Lymphoma

88
Q

t(8;14)

A

Burkitt Lymphoma

89
Q

Reed-Sternberg cells

A

Hodgkin Lymphoma

90
Q

Popcorn cells

A

Nodular L-P Hodgkin Lymphoma

91
Q

Lacunar cells

A

Nodular Sclerosis Hodgkin Lymphoma

92
Q

Collagen or reticulin background

A

Lymphocyte depletion Hodgkin Lymphoma

93
Q

therapy induced lung disease

A

bleomycin

94
Q

anti-CD20 “difference maker” tx

A

rituximab

95
Q

prototypical agressive NHL

A

Diffuse Large B Cell

96
Q

cyclin D+

A

Mantle Cell Lymphoma

97
Q

H. pylori

A

MALT Lymphoma

98
Q

prototypical T-cell lymphoma

A

Mycosis Fungoides

IHO week 6 and Final (14 decks)

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