Block 5 highish yield Flashcards by Weston Tardy

Q

reduced IL-2 and expression of IL-2R (CD25) is a result of:

A

reduced antigen exposure

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Q

no Tregs

A

IPEX

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Q

problem caused by IPEX

A

out of control T-cells

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Q

Treg autocrine cytokine?

A

IL-35

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Q

genetic cause of IPEX

A

mutated FOXP3

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Q

overexpression of thyroid hormones

A

Grave’s disease

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Q

high MHC II induces

A

Th1

Th17

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Q

low MHC II induces

A

Th2

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Q

CXCR3

CCR5

A

Th1

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Q

CCR3

CCR4

CCR8

A

Th2

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Q

CCR6

A

Th17

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Q

Mutation in CCR5

A

HIV resistance

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Q

anti-nuclear antibodies

A

SLE

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Q

dsDNA and Smith (Sm) antigen antibodies

A

SLE

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Q

SLE hypersensitivity

A

Type III

immune complex mediated

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Q

anti-phospholipid antibodies

A

SLE

Q

acute necrotizing vasculitits

A

SLE

Q

SS-A

HLA-DR3

A

Subacute cutaneous LE

Q

autoantibodies for CCPs

A

RA

Q

dry eyes

dry mouth

SS-A

SS-B

A

Sjogren Syndrome

Q

perivascular fibrosis

A

systemic sclerosis

Q

Scl-70 antibodies

A

systemic sclerosis

Q

anti-centromere antibodies

A

CREST syndrome

Q

Raynaud’s

A

systemic sclerosis

Q

anti-U1-RNP

A

mixed connective tissue disease

Q

Btk

A

XLA

Q

B-cells present

don’t differentiate into plasma cells

A

CVID

Q

failure of thymus development

A

DiGeorge

Q

22q11

A

DiGeorge

Q

X-linked recessive CD40L mutation

A

Hyper IgM syndrome

Q

P. jiroveci

A

Hyper IgM syndrome

Q

defect in humoral and cell mediated immunity

usually X-linked gamma chain cytokine receptor mutation

A

SCID

Q

ADA

A

SCID

Q

Thrombocytopenia

Eczema

variable loss of cell mediated immunity

A

Wiskott-Aldrich

Q

inability to clear EBV

infectious mono

B cell lyphoma

A

X-linked lymphoproliferative disorder