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IHO week 6 and Final > Block one high yield > Flashcards

Block one high yield Flashcards

1
Q

pluripotent stem cell + IL-3

A

lymphoid progenitor

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2
Q

pluripotent stem cell + IL-3 + GM-CSF

A

myeloid progenitor

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3
Q

plasma vs serum?

A

plasma has fibrinogen

serum does not

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4
Q

3 RBC cytoskeleton proteins:

A

spectrin

ankyrin

actin

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5
Q

no ankyrin inRBC –> ?

A

hereditary spherocytosis

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6
Q

myeloperoxidase

A

neutrophil

Azurophilic granule

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7
Q

lysozyme

lactoferrin

A

neutrophilic specific granules

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8
Q

gelatinase

A

tertiary granules

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9
Q

major basic protein

cationic protein

A

Eosinophil specific granules

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10
Q

Bid/Bax

A

pro-apoptotic

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11
Q

Bcl-2/Bid

A

antiapoptotic

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12
Q

genome: dsRNA segmented
tropism: pro-erythroblasts

travel to mountain west

A

Colorado tick fever virus

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13
Q

genome: dsDNA
tropism: systemic; latent in CD34+ cells (monocyte–>macrophage)

heterophile Ab negative

Owl’s eyes cells

Congenital –> deafness

A

Cytomegalovirus

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14
Q

genome: dsDNA
tropism: CD4+ T cells, others: PBMNCs, epithelial cells

exanthem subitum (aka roseola): rash that develops after a fever resolves

heterophile Ab negative mononuceosis

A

HHV6, HHV7

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15
Q

genome: dsDNA

tropism:
Acute: epithelial cells of oropharynx (supports lytic life cycle)
Latent: B cells

infectious mononucleosis: Heterophile Ab positive mono

Burkitt lymphoma: t(8:14)
Hodgkin & non-Hodgkin lymphoma
nasopharyngeal lymphoma
X-linked lymphoproliferative disease: inherited mutation in SAP adapter

A

Epstein Bar virus

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16
Q

genome: dsDNA
tropism: epithelial cells; B cells

in immunocompromised patients only:

primary effusion lymphoma

multifocal Castlemans disease

A

Karposis sarcoma virus

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17
Q

genome: ssRNA + or -
tropism: erythroid progenitor cells

NO envelope

erythema infectiosum: fiery red rash on cheek.

Transient aplastic crisis: in patients with underlying anemia

A

parvovirus B19

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18
Q

genome: ssRNA+
tropism: T-cells

Acute T cell lymphoma / leukemia (ATL): Viral transcription factor Tax drives proliferation; blocks apoptosis.

HAM/TSP: Inflammation on the spine

A

Human T-cell Lymphoma virus 1 and 2

1 > CD4’s

2> CD8’s

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19
Q

genome: ssRNA -
tropism: macrophages
capsid: HELICAL

Hemorrhagic fever

A

Ebola

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20
Q

T-cell zone of lymph node

A

paracortex (deep)

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21
Q

Lymph flow through node…

A

Afferent lymphatic vessels

Subcapsular sinus

Trabecular sinus

Paracortical sinus

Medullary sinus

Efferent lymphatic vessel

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22
Q

Prevents antigen in blood from entering thymic cortex

A

Blood-thymus barrier

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23
Q

Largest lymphatic organ

A

spleen

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24
Q

TLR ?

dsRNA

A

TLR 3

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25
Q

TLR ?

LPS

A

TLR 4

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26
Q

TLR ?

Triacyl Lipoprotein

A

TLR 1 and 2

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27
Q

TLR ?

Diacyl Lipoprotein

A

TLR 6 and 2

28
Q

TLR ?

flagellin

29
Q

TLR ?

ssRNA

30
Q

TLR ?

CpG-DNA

31
Q

E-selectin binds:

32
Q

Leukocyte adhesion molecules:

A

CR3/LFA-1 —– ICAM-1

33
Q

GM-CSF + G-CSF + IL-3 = ?

A

neutrophil

34
Q

GM-CSF + IL-3 + IL-5 = ?

A

eosinophil

35
Q

GM-CSF + IL-3 + IL-4 = ?

36
Q

GM-CSF + M-CSF + IL-3 = ?

37
Q

monocyte + M-CSF + GM-CSF = ?

A

macrophage

38
Q

monocyte + GM-CSF + IL-4 = ?

39
Q
  1. IL-3

2. SCF + IL-2

40
Q

No GM-CSF

A

Congenital neutropenia

(no myeloid cells)

inc. bacterial infx

41
Q

microcytic, hypochromic RBCs

anisocytosis (unequal size)

poikilocytosis (funny shape)

GI bleeding

A

Iron deficiency anemia

**abnormal iron studies

42
Q

Iron transporter in blood

A

transferrin

43
Q

Iron state that binds O2

A

Fe2+ ferrous

44
Q

Fe3+

A

ferric

“methemoglobin”

45
Q

craving dirt, ice, windex

A

Pica

iron deficiency anemia

46
Q

TIBC in Fe deficiency?

47
Q

ferritin in Fe deficiency

48
Q

defective DNA synth

B12/folate def

hypersegmented neuts

A

Megaloblastic anemia

49
Q

lack of intrinsic factor on gut epithilial cells

A

pernicious anemia

**can’t absorb B12

50
Q

normochromic, normocytic

spherocytes

targets, sickles, fragmented RBCs

A

Hemolytic anemia

51
Q

anemia, jaundice, splenomegaly

**parvovirus maybe

A

Hereditary spherocytosis

52
Q

IgG

Spleen

Spherocytes

A

Warm Autoimmune Hemolytic Anemia

53
Q

IgM, complement

some intravascular hemolysis

mostly spleen

agglutination

A

Cold autoimmune hemolytic anemia

*IgM falls off in warm body parts

54
Q

Isoniazid tx of TB associated with?

A

B6 deficiency

55
Q

Increased indirect (unconjugated) bilirubin associated with?

56
Q

Increased direct (conjugated) bilirubin associated with?

A

biliary obstruction

57
Q

Sporadic Porphyria cutanea tarda associated with?

58
Q

Increased hepcidin?

A

Anemia of Chronic Disease

59
Q

Vegan’s don’t absorb iron as well as meat eaters because?

A

Veggies have Fe3+ (ferric)

60
Q

Long term Iron storage

A

hemosiderin

61
Q

Lets Iron out of cells

A

Ferroprotin

62
Q

Blocks ferroportin, keeping Fe in cells:

63
Q

Increased Hepcidin probably means:

A

Anemia of chronic disease

64
Q

Decreased hepcidin means:

A

iron over load—-to much iron gets through ferroportin into blood

65
Q

HFE gene mutation

A

hereditary hemachromatosis

decreased hepcidin expression

inc serum iron

66
Q

Triad sx for hereditary hemachromatosis

A
  1. DM
  2. Hepatomegaly
  3. Hyperpigmentation
67
Q

Tx for hemachromatosis

A

phlebotomy

IHO week 6 and Final (14 decks)

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