Drugs for final buzzwords Flashcards by Weston Tardy | Brainscape

Q

FGF inhibitors

TERATOGENIC (phocomelia)

A

Thalidomide

also: lenalidomide, Pomalidomide

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

STI of VEGF

Raf

CHF/MI, teratogenic

HTN, hemorrhage

A

SoRAFinib

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

STI of VEGF

cKIT

skin discoloration

A

Sunitinib

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

STI of VEGF

cKIT

Fatal Hepatotoxicity

Torsuad’s, prolonged QT

A

Pazopanib

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Methotrexate overdose rescue

A

Glucarpidase

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

t(15;17) AML M3

induces differentiation

A

trentinoin, arsenic trioxide

ATRA

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

retinoid receptor agonist

increased cell differentiation–> death

A

bexarotene

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Protects bladder from Cyclophosphamide

A

MESNA

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

fusion protein analog of thrombopoietin

A

Romiplostim

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

26s proteosome

A

Bortezomib (reversible)

Carfilzomib (irreversible)

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

HDAC

cutaneous t cell lymphoma

A

Vorinostat

Romidepsin

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

HER2 STIs

A

Trastuzamab

Pertuzumab

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

EGFR STIs

ATP binding site competitors and MABs

A

CETUXIMAB

ERLOTINIB

GEFITINIB

PANITUMUMAB

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

BCR-ABL STI

A

imatinib

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

FK-binding protein

immunosupressor

Antibiotic

A

Tacrolimus

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

CD20

A

rituximab

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

CD52

A

alemtuzumab

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

VEGF MAB

used with 5-FU

A

Bevacizimab

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

ribonucleotide reductase

syncronizes cell in radiation sensitive G1 phase

A

Hydroxyurea

Q

treats Tumor Lysis Syndrome from 6-MP

A

allopurinol

**decrease 6-MP

Q

Allows higher dose of MTX

Reduced folate carrier uptake

A

Leukovorin

Q

DNA pol inh.

A

–abines

**except fludarabine

Q

ribonucleotide reductase

purine analog

A

fludarabine

Q

Purine analogs

PNP

HGPRT

A

6-MP

6-TG

Q

most toxic nitrogen mustard

alkylating agent

A

mechlorethamine

Q

nitrogen mustard

alkylating agent

Hemorrhagic cystitis

A

cyclophosphamide

Q

nitrosoureas

crosslink DNA

lipid soluble

A

Carmustine

Lomustine

Q

HIV drugs

4 nucleoSide RTIs

A

Zidovudine (Azidothymidine or AZT)

Lamivudine

Emtricitabine

Abacavir

Q

HIV drugs

1 nucleoTide RTI

A

Tenofivir

Q

2 NNRTIs

A

Efavirenz

Etravirine

Q

HIV drugs

3 protease inhibitors

A

Ritanovir

Atazanavir

Darunavir

Q

HIV drug

fusion inhibitor

binds gp 41

A

Enfuvirtide

Q

HIV drug

integrase inhibitor

A

Raltegrovir

Q

HIV drug

binds HOST CCR5

A

Maraviroc

Q

Antiplatelet drugs

ADP analogs

** CLOP CLOP PRA

A

Clopidogrel

Ticlopidine

Prasugrel

Q

Antiplatelet drugs

GP IIb/IIIa inhibitors

**EAT

A

Eptifibatide

Abciximab

Tirofiban

Q

Antiplatelet drug

Increases cAMP

Phosphodiesterase 3 inhibitor

vasodilator

use in combo w/ASA or Warfarin

A

Dipyridamole

Q

Indirect thrombin inhibitors

bind AT III

inhibit thrombin and Xa

A

heparins

Fondaparinux

Q

Antidote for heparin OD

A

Protamine

Q

Bind directly to thrombin

**BAD

A

Bivalirudin

Argatroban

Dabigatran

Q

Direct Xa inhibitors

**RAE bans

A

Rivoroxaban

Apixaban

Edoxaban

Q

vit K dependent clotting factors

A

II

VII

IX

X

Protein C

Q

More active enantiomer of Warfarin

A

S

Q

Two older fibrinolytics

A

Streptokinase

Urokinase

Q

tPA fibrinolytics

**ART–teplases

A

Alteplase

Reteplase

Tenecteplase