Drugs for final buzzwords

Question 1

FGF inhibitors

TERATOGENIC (phocomelia)

Answer 1

Thalidomide

also: lenalidomide, Pomalidomide

Question 2

STI of VEGF

Raf

CHF/MI, teratogenic

HTN, hemorrhage

Answer 2

SoRAFinib

Question 3

STI of VEGF

cKIT

skin discoloration

Answer 3

Sunitinib

Question 4

STI of VEGF

cKIT

Fatal Hepatotoxicity

Torsuad’s, prolonged QT

Answer 4

Pazopanib

Question 5

Methotrexate overdose rescue

Answer 5

Glucarpidase

Question 6

t(15;17) AML M3

induces differentiation

Answer 6

trentinoin, arsenic trioxide

ATRA

Question 7

retinoid receptor agonist

increased cell differentiation–> death

Answer 7

bexarotene

Question 8

Protects bladder from Cyclophosphamide

Answer 8

MESNA

Question 9

fusion protein analog of thrombopoietin

Answer 9

Romiplostim

Question 10

26s proteosome

Answer 10

Bortezomib (reversible)

Carfilzomib (irreversible)

Question 11

HDAC

cutaneous t cell lymphoma

Answer 11

Vorinostat

Romidepsin

Question 12

HER2 STIs

Answer 12

Trastuzamab

Pertuzumab

Question 13

EGFR STIs

ATP binding site competitors and MABs

Answer 13

CETUXIMAB

ERLOTINIB

GEFITINIB

PANITUMUMAB

Question 14

BCR-ABL STI

Answer 14

imatinib

Question 15

FK-binding protein

immunosupressor

Antibiotic

Answer 15

Tacrolimus

Question 16

CD20

Answer 16

rituximab

Question 17

CD52

Answer 17

alemtuzumab

Question 18

VEGF MAB

used with 5-FU

Answer 18

Bevacizimab

Question 19

ribonucleotide reductase

syncronizes cell in radiation sensitive G1 phase

Answer 19

Hydroxyurea

Question 20

treats Tumor Lysis Syndrome from 6-MP

Answer 20

allopurinol

**decrease 6-MP

Question 21

Allows higher dose of MTX

Reduced folate carrier uptake

Answer 21

Leukovorin

Question 22

DNA pol inh.

Answer 22

–abines

**except fludarabine

Question 23

ribonucleotide reductase

purine analog

Answer 23

fludarabine

Question 24

Purine analogs

PNP

HGPRT

Answer 24

6-MP

6-TG

Question 25

most toxic nitrogen mustard alkylating agent

Answer 25

mechlorethamine

Question 26

nitrogen mustard alkylating agent Hemorrhagic cystitis

Answer 26

cyclophosphamide

Question 27

nitrosoureas crosslink DNA lipid soluble

Answer 27

Carmustine Lomustine

Question 28

HIV drugs 4 nucleoSide RTIs

Answer 28

Zidovudine (Azidothymidine or AZT) Lamivudine Emtricitabine Abacavir

Question 29

HIV drugs 1 nucleoTide RTI

Answer 29

Tenofivir

Question 30

2 NNRTIs

Answer 30

Efavirenz Etravirine

Question 31

HIV drugs 3 protease inhibitors

Answer 31

Ritanovir Atazanavir Darunavir

Question 32

HIV drug fusion inhibitor binds gp 41

Answer 32

Enfuvirtide

Question 33

HIV drug integrase inhibitor

Answer 33

Raltegrovir

Question 34

HIV drug binds HOST CCR5

Answer 34

Maraviroc

Question 35

Antiplatelet drugs ADP analogs ** CLOP CLOP PRA

Answer 35

Clopidogrel Ticlopidine Prasugrel

Question 36

Antiplatelet drugs GP IIb/IIIa inhibitors **EAT

Answer 36

Eptifibatide Abciximab Tirofiban

Question 37

Antiplatelet drug Increases cAMP Phosphodiesterase 3 inhibitor vasodilator use in combo w/ASA or Warfarin

Answer 37

Dipyridamole

Question 38

Indirect thrombin inhibitors bind AT III inhibit thrombin and Xa

Answer 38

heparins Fondaparinux

Question 39

Antidote for heparin OD

Answer 39

Protamine

Question 40

Bind directly to thrombin **BAD

Answer 40

Bivalirudin Argatroban Dabigatran

Question 41

Direct Xa inhibitors **RAE bans

Answer 41

Rivoroxaban Apixaban Edoxaban

Question 42

vit K dependent clotting factors

Answer 42

II VII IX X Protein C

Question 43

More active enantiomer of Warfarin

Answer 43

S

Question 44

Two older fibrinolytics

Answer 44

Streptokinase Urokinase

Question 45

tPA fibrinolytics **ART--teplases

Answer 45

Alteplase Reteplase Tenecteplase