Throat symptom/complaint Flashcards

1
Q

Predisposing factos for Candida pharyngitis

A
HIV infection
Diabetes mellitus
Broad spectrum antibiotics
Corticosteroids, including inhalers
Dentures
Debility
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2
Q

Symptoms and signs of Candida phyaryngitis

A

Presentation - Milky white growths on palate, buccal, gingival mucosa, pharynx and dorm of the tongue.
If scraped away a bleeding ulcerated surface remains
Metallic taste
Sore throat and tongue
dysphagia

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3
Q

Mx of Candida pharyngitis

A

Determine underlying cause
Nystatin suspension rinse and swallow QID
or amphotericin 10mg lozenge dissolved slowly in oral cavity, 6hrly for 7-14days.

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4
Q

Presentation of Hand, foot and mouth

A
fever sore throat
dysphagia
oral
tiny papulovesicles
erythematous halo
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5
Q

Cause of Hand, foot and mouth

A

Coxsackie virus A

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6
Q

Transmission and incubation of hand, foot and mouth

A

Face - oral and incubation for 2-6 days

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7
Q

Cause of Glandular fever

A

Epstein Barr Virus (Infectious monocytosis)

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8
Q

Transmission of Epstein Barr Virus

A

Youth, close contact, saliva, kiss

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9
Q

Incubation time for EBV

A

1-2 months

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10
Q

Pathogenesis of EBV

A

EBV infect epithelium cells of the URT and infect B lymphocytes where they start multipling in the B lymphocytes. From there they spread and infect other organs by infected B lymphocytes.
EBV specific CD8+ T cells - defines (atypical lymph)

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11
Q

Symptoms of EBV

A
15-25 yrs with a painful throat that take 7d to reach the peak.
Prodromal fever, malaise, lethargy
Anorexia, myalgia
Nasal quality voice
Skin Rash
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12
Q

Signs of EBV infection

A
URTI+
Petechiae on palate
Enlarged tonsils with or without
Periorbital oedema
Lymphadenopathy
Splenomegaly - enlarged spleen = easy rupture - youth death
Hepatitis
The rash - Primary rash 5%, Secondary rash when treatment with ampicillin, amoxycillin and some with penicillin
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13
Q

Cx of EBV infection

A

Hepatitis
Spleen rupture - they can die from minor trauma
Organ failure - fatal

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14
Q

Dx of EBV infection

A

FBC - Absolute lymphocytosis
Blood firm - atypical lymphocytes
heterophil antibodies or Monospot test or EBV IgM test

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15
Q

Tx of EBV infection

A

Prognosis - self limited 4-6 wks
Symptomatic support - paracetamol
Parenteral corticosteroids only in most severe cases
Hydration - admit if unable to tolerate fluids

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16
Q

Symptoms of Diptheria

A
Insidious onset
Fever
SOB
Sore throat
Dysphagia
Cough
Nausea and vomiting
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17
Q

Signs of Diptheria

A
Pharynx inflamed and swollen with enlarged tonsils
Pseudomembrane
Hoarse voice
Lymphadenopathy
Cutaneous diphtheria (non healing ulcer)
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18
Q

Cx of Diptheria

A

Aspiration of pseudomembrane and airway obstruction
spread of exotoxin to cause myocarditis and HF
Peripheral neuritis

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19
Q

Tx of Diptheria

A

Throat swabs
Antitoxin
Penicillin or erythromycin 500mg QID for 10 days
Isolate patient

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20
Q

Cause of diptheria

A

Corynebacterium diphtheria which is gram +ve, pleomorphic bacilli, with exotoxin AB

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21
Q

Prevention of diptheria

A

DPT at 2m, 4m, 6m, 4yr, 10yr, 15yr and booster every 10yrs

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22
Q

Pathogenesis of diptheria

A

Infection results in mucosal necrosis with fibrinopurulent exudate (pseudomembrane).

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23
Q

Most common causes of Rhinitis

A
Rhinovirus 
most common cause
>100 serotypes
Other causes
Influenza
Parainfluenza
Corona (SARS)
Adenovrius 
RSV
May be bacteria after 7-10 days
Allergy - frequent or persistent symptoms
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24
Q

Rhinovirus
Transmission
Incubation period
and epidemiology

A
Seasonal
Highly contagious
Transmission Droplet spread by sneezing, coughing, hand contact with the nose, eyes or face.
Incubation period 2-4 days
Prevention hand hygiene
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25
Pathogenesis of Rhinitis
Acute serous inflammation called Catarrhal = excess mucous | - infection -> mediator ->vasodilation -> excess mucous.
26
Red flags of rhinitis
Severe facial pain | severe headache
27
Symptoms of Rhinitis
Sneezing coughing Malaise lasting 3-6 days unilateral symptoms may be foreign body in children or malignancy in adult
28
Cx of Rhinitis
Secondary bacterial infection is common = suppurative Sinusitis Pharyngitis Tonsilitis otitis media Septicemia Nasal polyps - inflammatory (allergy) - long term complication in hypersensitive people
29
Tx of Rhinitis
Good health and nutrition | Pseudoephedrine
30
Presentation of Peritonsillar abscess/Quinsy
``` Presentation of tonsillitis that is followed by increasing difficulty in swallowing the trismus (spasm of jaw = lock jaw) Usually ill with high fever +/- Dysphagia Odynophagia Most common in teenager and young adults ```
31
Signs of peritonsillar abscess/Quinsy
Pooling of secretion in treat Difficulty moving/uwilling to move their neck Hyperextension of neck - usually unilateral
32
Most likely organism that causes peritonsillar abscess/Quinsy
polymicrobial including staph aureus and street pyogenes usually GABHS or anaerobes Occasionally Haeophilus sp and Stagpylococcus aurues
33
Tx of Peritonsillar abscess/Quinsy
Admit to hospital Antibiotics - procaine penicillin IM or clindamycin IV Benzylpenicillin 6hrly ENT Surgery - Aspiration or drainage
34
Symptoms of Croup
presentation – coryza present or absent, seal-like harsh barking cough, inspiratory stridor and variable degree of distress, chest wall retraction in 6month to 3yr and increases in winter ``` Starts with coryza symptoms then Barking cough Inspiratory Stridor - loudness does not correlate with severity of obstruction +/- Wheeze +/- Hoarse voice +/- Fever but no signs of toxicity Increased Work of breathing Worse at night, peaks night 2 or 3. Then settles down. ```
35
Signs of Croup
Minimal, don't examine the throat or upset the child
36
Characteristics of Mild Croup
``` Behaviour- normal Stridor - Barking cough, Stridor only when active or upset RR - normal Accessory muscle use - none or minimal Oxygen - None ```
37
Characteristics of moderate Croup
Behaviour - some/intermittent irritability Stridor - some at rest RR - increased, Tracheal tug, nasal flaring Accessory muscle- moderate chest wall retraction O2- none
38
Characteristics of severe croup
Behaviour - increase irritability and/or lethargy Stridor- at rest RR- Marked increase or decrease, tracheal tug, nasal flaring Accessory muscle - marked chest wall retraction O2 - Hypoxia is a late sign of significant upper airways obstruction.
39
Pt who are at risk of severe Croup
``` Preexisting narrowing of upper airways Down’s syndrome Sub-glottic stenosis or chronic stridor from other cause other neurological disorders Previous admission with severe croup ```
40
Causes of Croup
Respiratory syncytial | Parainfluenza virus
41
DDX for Croup
Inhaled foreign body Epiglottis Bacterial tracheitis
42
Mx for severe croup
Minimal handling nebuliser adrenalin - 1mL of 1% adrenaline solution plus 3ml Normal saline or 4 ml of adrenaline 1:1000 And Give 0.6 mg/kg (max 12mg) IM/IV dexamethasone Improvement - observe for 4 hours post adrenaline then consider discharge once stridor free at rest Improvement than deterioration - give further doses of adrenaline, Then consider admission/transfer as appropriate No Improvement - reconsider diagnosis. Acute upper airway obstruction
43
Mx of mild to moderate Croup
Prednisolone 1mg/kg and prescribe a second dose for the next evening Or A single dose of oral dexamethasone 0.15mg/kg Observe for half an hour post steroid administration Discharge once stridor-free at rest
44
When to consult paediatric team or transfer
Consider consultation with local paediatric team when severe airways obstruction no improvement with nebuliser adrenaline Child has risk factors Consider transfer when No improvement following nebuliser adrenaline. > 2 doses of nebuliser adrenaline are required Children requiring care above the level of comfort of the local hospital
45
Discharge requirements for croup
Four hours post nebulised adrenaline (if given) and/or half an hour post oral steroid, and stridor free at rest - Parents should be advised and able to seek help if stridor at rest regardless of whether they have received steroids
46
DDX for Pharyngitis
``` Bacteria: Group A Strep pyogenes 15-30% of children with sore throat (3yr to 15yr) Virus: 33% Rhino, Adeno, EBV etc - common cause of sore throat in children. Fusobacterium necrophorum 15% Unknown 22% Uncommon Spirochets (Vincent ́s angina) STI: Gonorrhoea, Chlamydia, Syphilis, HIV Corynebacterium influenza or diphtheria Arcanobacterium haemolytic Streptococci of group C or G Haemophilus influenza TB Cancer in tonsil. ```
47
Who get Pharyngitis
Age group - uncommon in
48
Features of a Streptococcal features
``` Constitutional symptoms fever >38 Toxicity absence of cough Tonsillar exudate and swelling >6yr Swollen tender anterior cervical LN. Other symptoms difficulty in swallowing Significant pain including pain on talking foul smelling breath ```
49
signs of Pharyngitis
Pharynx very inflamed and oedematous Tonsils swollen with pockets of yellow exudate on surfaces Very tender enlarge tonsillar LN
50
Modified Centor criteria
``` Tonsillar exudate or erythema Anterior cervical adenopathy Cough absent Fever present Age 3-14 +1, 15-45 =0, >45 -1 Score 4-5 Tx ABx Score 2-3 Perform rapid antigen test. + = Abx, - = throat culture Score 0-1 symptomatic tx ```
51
Indications for antibiotics in pharyngitis
Servere tonsillitis with above features of GABHS existing RHD at any age Scarlet fever Peritonsillar cellulitis or abscess pt 2-25 with presumptive FABHS for special communities e.g. remote that have a high incidence of ARF ?Vomiting or diarrhoea
52
Mx for Streptococcal pharyngitis
Antibiotic if indicated Phenoxymethyl Penicillin BD for 10 days or Cephalexin or Roxithromycin if allergic Analgesics Corticosteroid if severe pain and unresponsive to analgesia
53
when to admit or transfers to tertiary centre for pt with Pharyngitis
Suspected upper airway obstruction Systemically unwell patients Evidence of acute complications e.g. abscess formation, upper airway obstruction Significant comorbidity e.g. immunosuppression (after discussion with relevant treating team)
54
Common causes of Sore throat
``` Pharyngitis 50% virus Coryza prodromata, hoarseness, cough, conjuctivitis, nasal stuffiness Streptococcal GABHS Tonsillitis Chronic sinusitis with postnasal drip Oropharyngeal candidiasis Epstein-Barr mononucleosis ```
55
Sore throat, Serious disorders not to be missued
CV- ANGINA, MI Severe infections Epiglottitis - Haemophilus influenza in children 2-4 years, Acute onset short febrile illness, respiratory difficulty but no cough and unable to swallow. Streptococcal pharyngitis with Cx Quinsy - peritonsillar abscess Diphtheria HIV Neoplasia - Cancer of oropharynx or tongue. Pharyngeal cancer = painful swallowing +referred ear pain + hoarseness Blood Dyscrasias - agranulocytosis, Acute leukaemia, Foreign body- sudden onset of throat pain, then drooling and dysphagia
56
Sore throat - Diagnostic pitfalls
classic being to Dx exudative tonsillitis of EBM as streptococcal tonsillitis and prescribe penicillins which may precipitate a severe rash Primary HIV infection may present with sore throat throat.
57
Sore throat - seven masquerades
``` Depression Diabetes - Candida Drugs Anaemia -possible Thyroid disorder - thyroiditis Spinal dysfunction - cervical ```
58
Red flags of a sore throat
Persistent high fever Failed antibiotic tx Medication - induced agranulocytosis Mouth drooling - consider epiglottis - don’t examine throat Sharp pain on swallowing - foreign body Marked swelling of quinsy Candidiasis - consider diabetes or immunosuppression
59
What to ask on a hx for someone with a sore throat
differentiate between sore throat, deep pain or neck pain Ass symptoms Metallic taste in mouth, fever, URTI, Other pain e.g. ear pain, nasal stuffiness or discharge and cough PmHx - Asthma, Med - Corticosteroid inhaler Immunisation - especially about diphtheria Social Hx - Smoker, environmental irritants Screen for Angina
60
What to look for on examination of a pt with a sore throat
GI - toxicity , anaemic pallor of leukaemia, Nasal stuffiness of infectious mononucleosis. Characteristic halitosis of streptococcal throat. Inspect - ears and check sinus areas, oral cavity and pharynx for ulcers, abnormal masses and exudates. Note if uvula and soft palate, tonsils, faces or pharynx are swollen, red or covered in exudate. Palpate - neck for soreness and lymphadenopathy
61
Tx for a sore throat
Depends on cause Supportive symptomatic ts adequate nothing fluids e.g. icy poles Analgesia - Aspirin for adults and paracetamol for children Rest with adequate fluid intake Soothing gargles Advise against overuse of throat lozenges and topical sprays ->sensitise the throat. Limit use of decongestants to 3days