Diabetes Flashcards

1
Q

Symptoms of DKA

A
Polyuria
polydipsia
weight loss
weakness
Nausea
vomiting
leg cramps
blurred vision
abdominal pain
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2
Q

Signs of DKA

A
Kussmaul breathing (deep and laboured breathing), 
dehydration  
Hypotension - postural or supine
Cold extremities/peripheral cyanosis
tachycardia
smell of acetone
hypothermia
confusion, drowsiness, coma
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3
Q

How to differentiate between DKA and HONK

A

Different to DKA – severe hyperglycaemia = osmotic diuresis and lack of hydration
usually in old people with not enough water or complication of T2D
Causes osmotic diuresis and severe dehydration only (not ketone bodies or acidosis)
no nausea
no vomiting
no kussmaul breathing

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4
Q

Symptoms and signs of Hypoglycaemia

A
Causes  from lack of eating
sweating, 
tachycardia, 
dizziness, 
palpitation, 
Hunger
Anxiety
CNS confusion (remember back to EM - always check glucose in confused patients)
Drowsiness
Speech difficulty
Inability to concentrate
Incoordination
Irritability and anger
Nausea
Tiredness
Headache
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5
Q

Retinopathy of diabetes

A

Non proliferative = Cataract (sorbitol), Microaneursyms (Dots), Haemorrhages (Blots), Hard exudate, Soft/cotton wool infarcts
Proliferative = Neovascularisation, Retina sheet haemorrhages, Retinal detachment.

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6
Q

Nephropathy of diabetes

A

Nodular glomerulosclerosis
Pyelonephritis
Necrotising papilitis
Renal artery atherosclerosis

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7
Q

Neuropathy of diabetes

A

Focal demyelination due to microangiopathy and direct glycosylation
PNS - Sensory then motor. Bilateral, distal, pains and needles in glove and sock pattern. Progressive and irreversible
Visceral nerves
- CN = diplopia, bells palsy
- GIT - constipation or diarrhoea
- CNS - Postural hypotension

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8
Q

Dermatopathy of diabetes

A
Neuropathic ulcer (on pressure point, painless, hyperkeratosis around. Loss of sensation but blood flow not affected)
Diabetic Xanthoma (Red, yellow, pruritic, painful)
Gangree (most common)
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9
Q

Diagnosis of T2D

A

FBG >/= 7 on two separate occasions
2 hour postprandial >11 on OGTT on two separate occasions
HbA1c >6.5% on 2 separate occasion
Or symptomatic pt with 1 raised blood level.

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10
Q

Classic symptoms of uncontrolled diabetes

A
Polyuria (every 1hr or so)
Polydipsia
Loss of wt if type 1
Tiredness and fatigue
Characteristic breath
Propensity for infections sep, of the skin and genitals
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11
Q

Ix to order to screen for diabetes

A

After AUSRISK
FBG or RBG
Then HbA1c as not funded.

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12
Q

Mx of a new diabetic

A
Advise road traffic authority
Assess modifiable risk factors
Assess CVD risk
PAID tool
Refer to diabetes teams
Medication 
- Type 1 - Insulin. Basal bolus and Rapid if needed
- Type 2 - Lifestyle, Metformin or sulphonylureas or Alpha glucosidase inhibitors , or glitazones, or meglitinides.
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13
Q

Mx of diabetic

A
Achieve strict glycemic control 30min/d.
Referral to ophthalmologist
Goals of management
- No smoking
- Alcohol - = 2 drinks per day
Chronic disease plan
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14
Q

Examination of a diabetic patient

A

GI - Gait - ask the patient to walk
Overweight, acanthosis nigricans, hemochromatosis coloration. look behind neck
Dehydration. recent wt loss, pigmentation (haemochromatosis)
Vital signs: No change in O2 saturation, RR HR and BP if presenting alone. Increased BSL and increased BMI expected.
Diabetic foot exam
Inspection:
Structure – bunions, hallux valgus, pes-cavus, pes plantus
Vascular – pedal oedema, atrophic shiny skin, hair loss
Infection – check legs and feet for ulcers, including between toes, boils, Cellulitis
Neurological – Charcot’s joint, wasting of quadriceps
Other – necrobiosis lipoidica diabeticorum and diabetic dermopathy.
Top to bottom - Thigh wasting, charcot joint, Loss of hair, thin atrophic, shiny skin, pedal oedema, dry skin, diabetic dermopathy (pigment over skin), skin discolouration, venous stasis, fungal nail, thickening nail, boils, cellulitis, ulcer, hallaux values, bunions, calluses, Pes cavus/Pes planus.
Palpation: Feel warmth of legs, peripheral pulses and CRT.
Light touch at 10 points on foot, sharp touch on dorsum of foot, vibration at distal hallux, proprioception.
Perform a survey of muscle tone, power and bulk.
Perform reflexes at knee, ankle and plantar surface of foot.
For completion
Face - Fundiscopy for proliferative and non proliferative diabetic retinopathy or hypertension retinopathy. cataracts
Mouth - signs of infection and fetor, dehydration
CVS - Cardiomyopathy, IHD
Resp - signs of infection
GIT - injection site and fat atrophy.
Neuro - peripheral and central neuropathy

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15
Q

Q to ask a known diabetic

A
  • Age of Dx
  • Insulin required from the start?
  • Presentation that lead to Dx
  • what previous and current tx r u on?
  • Diet?
  • Self monitoring? ranges?
  • Previous hypos? sweating, confusion, malaise or LOC?
  • Does pt know what to do if hypo or hyper happens?
  • Hx of DKA and hospital admission?
  • Cx of diabetes e.g. eyes, nerves BV, kidneys
  • Any regular testing for Cx
  • How is the pt and their family coping
  • Ability to work?
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16
Q

Symptoms of Diabetes

A
Polyuria
Polydypsia
Polyphagia 
with hyperglycemia
\+/- fatigue and infections (e.g. candida)
altered peripheral sensations, 
frequent infections, 
visual changes and 
changes in skin pigmentation. 
Weight loss
17
Q

Causes of secondary diabetes

A

Excess hyperglycaemic stimulus =
Cushings, Phaeochromocytoma, acromegaly, steriod therapy
Beta cell destruction =
Pacnreatitis/ Tumors/Hemochromatosis (Bronze diabetes)
Infectious - congenital rubella, CMV, TB
Endocrinopathy, Down Syndrome

18
Q

Risk factors for T2D

A

Increase waist circumfance W=>88cm, M=>102cm
Increase BP >140/90
Increase triglycerides>1.7mmol/L

19
Q

What is metabolic syndrome

A

Central obesity
Hypertension >/=130
Hyperglycaemia FBG >5.5
dyslipidaemia = High TG and low HDL

20
Q

risk factors for insulin resistance

A
Metabolic syndrome
Obese
Asians
TB drugs, SSRI
Pregnancy
Acromegaly, cushing
Renal failure
Cystic fibrosis
Polycystic ovary
Werner's syndrome
21
Q

Treatment aim for T2D

A
Address vascular risk factors
Quit smokers and excess alcohol
Structured education on targets and motivation 
MDT
Foot care
Pre conception advice
Life style changes first
Medication - metformin, Statins and antihypertensive
Self monitoring
RV 3-6 months and evaluated yearly
22
Q

Cardiovascular risk factors

A

Modifiable risk factors
HTN, Tobacco, High blood glucose, unhealthy diet, cholesterol/lipids, over Wt/obesity
Non-modifiable risk factors
Age, male gender, fmHx.

23
Q

Targets for blood test for diabetes

A
FBG - 6-8
Pre-prandial blood glucose 6-8
Post prandial blood glucose 6-10
Hb1Ac 1
Total cholesterol
24
Q

Counsel a pt on metformin

A

Biguanide
Aim - increase insulin sensitivity and help wt
MOA - Reduces hepatic gluconeogenesis and hence insulin requirements
SE - nausea, diarrhoea, abdominal pain. No hypoglycaemia
Precautions - Avoid if eGFR 7 on highest dose 16wks after starting then add Sulfonylurea. Severe heart failur, liver disease or renal failure=Lactic acidosis and fatal metabolic Cx.
Dose - Immediate release 500g BD up to 1g TDS. Extended release 1g with evening meal up to 2g.

25
Q

Other pharmacological options other then metformin

A
Sulfonylureas - increase insulin secretion. risk of hypoglycaemia.
DPP 4 inhibitor
GLP 1 agonist
Basal insulin
Thiazolidinediones
26
Q

What is done at the 3-6 month RV

A
Symptoms and SMBG results
HbA1c
BP
Wt +/- waist circumference
Foot examination (high risk pt)
27
Q

What is done at the yearly RV

A
Blood lipids
Microalbuminuria and plasma creatinine/eGFR
Eye RV (2yrly if no retinopathy)
Foot examination (low risk pt)
Look at 
Mx goals
Smoking
healthy eating
Physical activity
Self care education
Medications
Immunisation 
T1D - autoimmune screen for TFT and coeliac.
28
Q

Tx of metabolic syndrome

A
Exercise
Statins
wt loss
antihypertensives
hypoglycaemic medications
Explain benefits as close relationship between depression and insulin resistance
29
Q

Symptoms of mild to moderate hyperglycaemia

A
Asymptomic
Thirst, poly uria and poly dipsia
Blurred vision
balanitis in men and pruritus vulvae in women
Lethargy adn somnolence
Weight loss and weakness
Anorexia and nausea
Recurrent skin infections
30
Q

Symptoms of severe hyperglycaemia

A

Severe thirst
Drowsiness or coma
Vomiting

31
Q

Classic presentation of T1D

A

Short Hx of severe symptoms

Sometimes with DKA

32
Q

Common presentations of T2d

A

Detected on screening
Or a long history of less severe symptoms.
Or as a complication
Eg infections, visual impairment, arterial disease, neuropathy, renal failure

33
Q

Diagnostic criteria for diabetes

A

1 abn blood test if symptomatic or 2 if asymptomatic
RBG equal to or greater than 11mmol/L
FBG equal to or greater than 7 mmol/L
OGTT 2hr equal to or greater then 11 mmol/L

34
Q

Criteria for impaired glucose tolerance

A

FBG less then 7
OGTT 2hr - between 7.8 to 10.9

*impaired fasting glycaemia if FBG is 6.1 to 6.9