THERAPEUTICS Flashcards
Antipsychotic with least effect on EEG?
the most?
Quetiapine 0.0%
clozapine?
CYP1A2
lease sexual SE antideprssant
most in breast milk
vortioxetine/rebox
fluoxetine
how long does risperidone take to reach a steady state?
6 - 8 weeks
Fluvoxamine
potent CYP1A2 inhibitor - has lots of interactions
e.g. increase theophylline levels and displace warfarin
overdose treatment
lithium
methadone
overdose treatment
lithium - haemodyalysis
methadone - naloxone
overdose treatment
phenelzine
barbituates
phenelzine - phentolamine
barbituates -alkalinsation of urine
overdose treatment
aspirin
amphetamine
dizaepam
amitryptilline
aspirin - alkalisation of urine
amphetamine - acidification of urine
diazapam- flumenazil
amitriptyline - diazepam for seizure and + anticonvulsants
clozapine target level
350-500mcg /L
what receptor is responsible for tolerance to hallucinogenic drugs>
down-regulation of 5-HT2A receptors
why do newer antipsyhcotics jave lower incidence of EPSEs?
5HT2 blockade - higher 5hT2A occupancy = lower EPSE
bipolar treatment for depression
- lithium
+ olanzapine + fluoxetome - quetiapine
- olanzapnie alone
- lamotragine
HALOPERIDOL
JANSENN
-HALO JANSENN
MONOAMINE OXIDATE MOA on enzyme
irreversible enzyme inhibition - takes 2. weeks til enzyme re-created
benzodiazepines effect on GABA a-?
full agonist
lithium MOA?
second messenger system
5ht1a -
5ht2
5ht1a = therpeutic affect of SSRI
5ht2 = sexual side effects (2c = 2c)
paroxetine (SSRI) MOA
has affinity for Hitsminergic H1 and D2 and 5ht2
half life of aripiprazole?
75 hours
