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MRPSYCH PART A > recalls mcq > Flashcards

recalls mcq Flashcards

1
Q

psilocybin MOA

A

5Ht2a agonist

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2
Q

atomoxetine MO

A

highly selective Noradrenaline re-uptuake inhibitor binds presynaptic membrane

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3
Q

Buprion MOA

A

Noradrenaline-Dopamine re-uptake inhibitor and nicotinic acetylcholine receptor antagonist

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4
Q

Eriksons stages Virtures

A

Hope Will purposely come to find love care and wisdom

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5
Q

Erkison stages basic conflicts

A

trust will automatically initiate industry to identify intimacy, generativity and integritiy

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6
Q

which disease loss of striatum?

A

huntingtons

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7
Q

drug with low bioavailability because of wide distribution

drug with low bioavailability because of poor absorption?

A

chlorpromazine

lurasidone

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8
Q

seretonin is a precursor for which monoamine?

A

melatonin

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9
Q

new treatment for alzheimers target

A

to stimulate alpha secretase enzyme to cut up B amyloid

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10
Q

low risk manic switch?
highest risk?

A

least buprion, most TCA

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11
Q

area for prosopagnosia?
blood supply?

A

fusiform gyrus
PCA- occipito-temporal junction

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12
Q

default mode network

A

Medial Prefrontal Cortex
Posterior Cingulate Cortex (PCC) + Precuneus:
Inferior Parietal Lobule
lateral temporal cortex
Hippocampus

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13
Q

chromosomal abnormality FTD

A
  • 17q21
    + progranulin 17,
    MAPT tau, 17,
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14
Q

Melanie Klein’s object relations theory

A

Paranoid-schizoid position = birth -6 months split good/bad

depressive position -central to Childs development from 6 months - views things as whole

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15
Q

Transcranial Magnetic stimulation for
- severe depression

A
  • DLPFC
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16
Q

Brain organoids

A

Are 3D, in vitro, self-organising brain tissue structures derived
–> 2ND TRIMESTER

from human pluripotent stem cells
- mimic the second-trimester human fetal brain

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17
Q

what stage K complexes?

A

NREM stage 2

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18
Q

empathy in brain

A

INSULA
- insulate people with a hug = feel empathy

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19
Q

dentate gyrus is part of?

A

hippocampus

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20
Q

lurasidone MOA

A

D2, 5HT2a, 5HT7
absorption affected by food intake - increases absorption
no affect QTC

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21
Q

CASPR

A
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21
Q

antidepressant no sexual SE

least

Delayed ejacluation

priapism

Tx? prem ejac

A

no sex SE- agomelatine, bupropion, moclobemide

least- reboxitine, mirtazapine,vortioxetine

delayed ejac- citalopram and fluoxetine
priapism- trazadone

Tx- prem ejac dapzetine SSRI

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22
Q

autoimmune encphalitis

  • low NA?
  • personality change + pain + myoclonic jerk?
A

low Na - LG11

personality change + pain
caspr2
caspar is an automatic abnormal jerk- ghost causes pain

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22
Q

NMDA most affinity which receptor?

A

Glutamate + glycine

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23
Q

encephalitis

flu like– > chewing

A

NDMA

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24
Q

which gene codes for alpha synculein

A

SNCA chromosome 4

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25
Q

component BBB

A

APP + p glycoprotein

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26
Q

reactive attachment disorder.

A

Minimal seeking of comfort

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27
Q

tine antipsychotic takes to reach peak plasma conc
quetiapine
aripiprazole

A

quetiapine - 1-2 hours (QUICK)
aripiprazole 3-5 hrs

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28
Q

complex PTSD vs PTSD

A

complex = poor interpersonal relationships + problems in affect regulation

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29
Q

metabolic syndrome present in CATIE trial

A

41-50%

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30
Q

altruisim and pain

A

altruism causes reduced physical perception of pain

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31
Q

increased maternal sensitivity during attachment behaviour is due to increased connection between

A

increased functional connectivity of hippocampus and amuygdala

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32
Q

In vivo measurement of neurotransmitters by which technique

A

MRS
magnetic resonance spectroscopy

33
Q

MRS uses H1

A

H1 GABA and Glutamate
and Phosphorous 31

34
Q

18F]fluorodeoxyglucose (FDG) is used in which technique

35
Q

Rate limiting step in Alcohol metabolism

disulifram acts on?

A

Alcohol dehydrogenase

disulifram acts on- aldehyde dehydrogenase

36
Q

Recombination fraction value the means that two genes will be independently assorted:

37
Q

effect of caffeine can be revered by?

A

adenosine receptor agonist

38
Q

Intellectual disability how many SD below mean?

39
Q

GABA is projected onto which cell type in the striatum:

A

Medium spiny neurones

40
Q

Enzyme deficient in acute porphyria

A

HMBS - hydroxymethlbilane synthase - Aut Dominant disorder

41
Q

what increases by 30% if taken with lithium?

A

amisulpride (+ other renally excereted drugs)

42
Q

which condition listed twice in ICD 11?

A

dissociative disorder
Catatonia

43
Q

Which antipsychotics don’t cross BBB

how do they cross?

A

sulpride and amisulpride

cross via transport proteins

44
Q

gait seen in Normal pressure hydrocephalus

45
Q

short term memory
iconic menory

A

stm 30 seconds

iconic 0.5 seconds

46
Q

clozapine in pregnancy

A

dose needs increasing

47
Q

big 5 model of personality ?

A

OCEAN
openness to experience
conscientiousness
extraversion
Agreeableness
Neuroticism

48
Q

Cells least likely to be affected by HIV in the brain?

49
Q

ion implicated in schizophrenia?

channel involved?

A

Calcium

Channel involved? - Potassium

51
Q

DAT SCAN - dopamine active transported

A

uses SPECT scan
looks at function of dopamine transporters- helps distinguish parkinsons from other disorders

52
Q

Rogerian psychotherapy

A

Motivational interviewing

53
Q

– Paramimia

A

cant express mood via expressions eg happy but look flat
mimia = gestures

54
Q

trinucleotide repeat
fragile X
huntingtons
freidrichs
myotonic dystrophy

A

fragile X- CGG
huntingtons CAG
friedticks ataxia - GAA
myotonic dystrophy - CTG

55
Q

raised D2 occupancy
raised D2 sensitivity

A

raised D2 occupancy - parkinsons
raised D2 sensitivity - tardive dyskinesia

56
Q

maslows hierachy

A

D needs - deficiency needs bottom 4
B needs = being needs. - top 1

57
Q

Heritability:

A

Genetic contribution to phenotypic variation in a POPULATION

58
Q

Area under curve

A

(plasma concentration) Exposure to drug overtime.

59
Q

Most important pathophysiology for Alzheimer’s:

A

Beta amyloid (extracellular) and tau (intracellular)

60
Q

Most reliable indicator with myocarditis due to clozapine:

A

Eosinophilia (most specific)

61
Q

Cue Exposure Therapy

A

individuals are exposed to relevant drug cues to extinguish conditioned responses.

62
Q

likert

semantic differential

A

likert
-agree – disagree

semantic differential
strong—-weak
love —-hate

63
Q

fetal malformation in Na valproate

A

congenital malformation 8-12%

developmental delay - 31-40%

64
Q

which enzyme metabolises clozapine?

A

CYP1A2 - smoking

65
Q

MOA
methadone
buprenorphine
naloxone
naltrexone

A

methadone - full Mu agonist
buprenorphine- partial Mu agonist
naloxone - Mu antagonist short acting
naltrexone- mu antagonist longer acting

66
Q

Ideational and Ideomotor both located

A

are dominate partial lobe lesions.

67
Q

Drug with relative D2/D3 receptor activity

drug with pure D2?

A

Amisulpride

pure d2 - sulpride

68
Q

The dorsal attention network (frontoparietal or central executive network):

A
  1. Dorsolateral prefrontal cortex.
  2. Intra-parietal sulcus (IPS) + lateral superior parietal lobule (together called
    posterior parietal cortex – PPC)
  3. Middle frontal gyrus/premotor junction
69
Q

The salience network:

A
  1. Anterior prefrontal cortex (aPFC)
  2. Dorsal anterior cingulate cortex (dACC)
  3. Anterior insula
  4. Frontal operculum
  5. Some subcortical structures (thalamus and putamen).
70
Q

most common site of methylation?

71
Q

second messenger of lithum

A

ITP - inositol channel

72
Q

Alzheimer increase by APOE 4 in heterozygote
Homozygote

A

heterozygote 3 times (Risk)

Homozygote / 10-30 times

73
Q

taupathy

familial FTD

picks

A

familial tau -ve, ubuquitin +ve

Pick’sDisease: Tau+ve,Ubiquitin +ve

most common FTD tau +ve, amyloid -ve, uhbiquitin +ve

74
Q

what antiepileptic causes aggressive behaviour

A

LVT = Levetiracetam > Vigabatrin > Topiramate
LETS VENT !

75
Q

frontal lobe % brain?

% prefrontal cortex

A

frontal love 41%

% prefrontal cortex 15%

76
Q

pregnancy changes

A

increase GFR +

increase PH if no other option

77
Q

wilsons chromosome

78
Q

mechanism of action of ketamine;-

A

NMDA antagonist non competitive

79
Q

Muscarinic receptor action are found

A

parasympathetic ganglia

82
Q

object permamence in which stage?

A

piaget
sensorimotor

83
Q

sternbergs theory?

A

triarchic theory

MRPSYCH PART A (23 decks)

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