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therapeutic antibodies Flashcards

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1
Q

Alemtuzumab targets ___

used in

A

CD52

CLL, MS

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2
Q

Rituximab targets

A

CD20

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3
Q

Bevacizumab targets

A

VEGF

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4
Q

Bevacizumab uses

A

Neovascular age-related macular degenaration, and macular edema
CRC
Renal CA
non small cell Lung Ca

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5
Q

Cetuximab targets:

A

EGFR (epidermal-growth factor)

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6
Q

Cetuximab can be used in

A

Stage IV CRC and head and neck cancer.

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7
Q

Trastuzumab target is

A

HER 2

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8
Q

Trastuzumab used in

A

Breast cancer

Gastric Cancer

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9
Q

with inhibition of TNF α there is ________

A

decreased inflammatory response

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10
Q

mention the PAIR diseases autoimmune

Arthritis WITHOUT rheumatoid factor (no anti-IgG antibody).

A

Psoriatic arthritis
Ankylosing spondylitis
IBD like Chron’s and UC
Reactive arthritis

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11
Q

How does Etarnecept works?

A

is a decoy for TNF α (not a monoclonal antibody)

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12
Q

Mention 3 TNF α inhibitors

A

Adalilumab
Infliximab
Golimumab

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13
Q

These are both used in MS

A

Daclizumab and Natalizumab (A4 integrin)

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14
Q

Eculizumab target is

A

Complement protein C5

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15
Q

Eculizumab is used to treat

A

Paroxysmal
Nocturnal
Hemoglobinuria

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16
Q

Abciximab targets

A

Platelet glycoprotein IIb/ IIIa

17
Q

Denusumab targets

A

RANKL

18
Q

Denusumab used in

A

Osteoporosis

19
Q

Omalizumab targets

A

IgE

20
Q

Omalizumab is used to treat

A

Refractory asthma

Prevents IgE binding

21
Q

Palivizumab is used to for

A

RSV ppx for high risk infant

22
Q

Palivizumab targets

A

RSV F protein

23
Q

This drigs binds to the epsilon chain of CD3 (T cells)

A

Muromonab-CD3 (OK3)

24
Q

key side effect of Muromonab-CD3 that occurs after the 1st or 2nd dose

A

Cytokine release syndrome…

premedication w/steroids and antihistaminics

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