therapeutic antibodies Flashcards
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Alemtuzumab targets ___
used in
CD52
CLL, MS
Rituximab targets
CD20
Bevacizumab targets
VEGF
Bevacizumab uses
Neovascular age-related macular degenaration, and macular edema
CRC
Renal CA
non small cell Lung Ca
Cetuximab targets:
EGFR (epidermal-growth factor)
Cetuximab can be used in
Stage IV CRC and head and neck cancer.
Trastuzumab target is
HER 2
Trastuzumab used in
Breast cancer
Gastric Cancer
with inhibition of TNF α there is ________
decreased inflammatory response
mention the PAIR diseases autoimmune
Arthritis WITHOUT rheumatoid factor (no anti-IgG antibody).
Psoriatic arthritis
Ankylosing spondylitis
IBD like Chron’s and UC
Reactive arthritis
How does Etarnecept works?
is a decoy for TNF α (not a monoclonal antibody)
Mention 3 TNF α inhibitors
Adalilumab
Infliximab
Golimumab
These are both used in MS
Daclizumab and Natalizumab (A4 integrin)
Eculizumab target is
Complement protein C5
Eculizumab is used to treat
Paroxysmal
Nocturnal
Hemoglobinuria
Abciximab targets
Platelet glycoprotein IIb/ IIIa
Denusumab targets
RANKL
Denusumab used in
Osteoporosis
Omalizumab targets
IgE
Omalizumab is used to treat
Refractory asthma
Prevents IgE binding
Palivizumab is used to for
RSV ppx for high risk infant
Palivizumab targets
RSV F protein
This drigs binds to the epsilon chain of CD3 (T cells)
Muromonab-CD3 (OK3)
key side effect of Muromonab-CD3 that occurs after the 1st or 2nd dose
Cytokine release syndrome…
premedication w/steroids and antihistaminics
