Biochem1

Question 1

Gq protein uses which 2nd messengers:

Answer 1

DAG, IP3, Ca++

Question 2

cAMP enzyme is

Answer 2

Adenyl cyclase

Question 3

cGMP uses which enzyme

Answer 3

Guanyl cyclase

Question 4

ANF and NO are examples of which 2nd messenger?

Answer 4

cGMP

Question 5

Once generated, cAMP and cGMP are slowly degraded by which class of enzymes?

Answer 5

PDEs

Question 6

E. Coli Heat-stable toxin binds and stimulates entorocytes increasing:

Answer 6

cGMP

Question 7

increasing cGMP.. decreases or increases smooth muscle relaxation?

Answer 7

increases smooth muscle relaxation

Question 8

Insulin and growth factors are what kind of receptors

Answer 8

Tyrosine kinase

Question 9

PI-3 kinase has what effect on muscle and adipose tissue?

Answer 9

increase GLUT -4 in membrane

Question 10

Ultimately insulin stimulation via its tyrosine kinase R may lead to ______ enzymes

Answer 10

Dephosphorylating enzyme

Question 11

Glucagon works through the _____ system to activate ______ favoring ____ or Rate limiting enzymes

Answer 11

cAMP
protein kinase A
Phosphorylation

Question 12

Trimeric G proteins are

Answer 12

Gq, Gs, Gi (seven -helix structure) and Gt rhodopsin is couples to Gt transducin

Question 13

ADP ribosylation increases :

Answer 13

cAMP

Question 14

Cholera toxin and E.coli (HL toxin) traveler’s diarrhea act on

Answer 14

Gs alpha

Question 15

bordetella pertussis inhibitis the inhibitor

Answer 15

Gi (increases cAMP)

Question 16

Lipid soluble hormones can diffuse through the membrane and ususally their domain is

Answer 16

Zn fingers

Question 17

in PIP 2 system which protein kinase is activated

Answer 17

protein kinase C

Question 18

Bite cells are characteristic of

Answer 18

glucose-6-phosphate dehydrogenase (G6PD) deficiency

Question 19

hydroxyurea inhbits

Answer 19

ribonucleotide reductase (in de novo pyrimidine synthesis)

Question 20

5 fluorouracil inhibits

Answer 20

thymidylate synthase in de novo pyrimidine synthase

Question 21

PRPP amidotransefarese is from which pathway

Answer 21

de novo purine synthesis

Question 22

allopurinol and 6 mercaptopurine block

Answer 22

PRPP amidotransferase in denovo purine synth pathway

Question 23

Amino acids necessary for Purine synthesis

Answer 23

GLYCINE
ASPARTATE
GLUTAMINE

Question 24

Rate Lim Enzyme in Urea cycle:

Answer 24

carbamoyl phosphatase synthetase I

Question 25

Regulator of Urea cycle

Answer 25

N acetylGlutamate (allosteric activator of carbamoyl phosphatase synthetase I)

Question 26

most common urea cycle disorder

Answer 26

Ornithine Transcarbamylase def