immunosupresants

Question 1

cyclosporine mechanism of action

Answer 1

Calcineurin inhibitor (T cells), binds cyclophilin and prevents IL2 transcription

Question 2

due to supression of T cell activation and surveillance pt is more prone to..

Answer 2

viral infections and lymphoma

Question 3

Tacrolimus binds _____ and inhbits____

Answer 3

FK

calcineurin

Question 4

both calcineurin inhibitors are highly (Tacrolimus and cyclosporine)

Answer 4

Nephrotoxic (tacrolimus and sirulimus)

Question 5

Syrolimus mechanism of action

Answer 5

Also inhibits T cell proliferation in response to IL-2. mTOR inhibitor

Question 6

Cyclosporine toxicity:

Answer 6

Nephrotoxic
HTN
hyperlipidemia
neurotoxicity 
gingival hyperplasia
hirsutism

Question 7

Tacrolimus toxicity:

Answer 7

same as cyclosporine, but NO gingival hyperplasia / hirsutism

Question 8

This immunosupresant is used specifically for kidney transplant rejection ppx

Answer 8

Sirolimus (Rapamycin)

Question 9

Sirolimus toxicity

Answer 9

NOT nephrotoxic

but leukopenia , pancytopenia, insulin resistance

Question 10

This monoclonal antibody binds to the IL-2 Receptor and ultimately blocks mTOR pathway of immune response

Answer 10

Basiliximab / daclizumab

Question 11

Toxicity of Basiliximab is

Answer 11

edema, HTN, tremor

Question 12

Antimetabolite precursor of 6MP , blocks nulcleotide synthesis

Answer 12

Azathriopine

Question 13

6MP, toxic metabolite of Azathriopine is degraded by which enzyme

Answer 13

xanthine oxidase

Question 14

Mycophenilate mofelate mechanism of action is

Answer 14

rev. inhibits IMP dehydrogenase preventing purine synthesis of B and T cells

Question 15

Mycophenilate has a important role in which dz

Answer 15

lupus nephritis

Question 16

How are steroids immunosupresants?

Answer 16

They inhibit TNF kappa B. supress both B and T cell