The parasympathetic nervous system

Question 1

What is the pre and post ganglionic nuerotransmitter

Answer 1

ACETYLCHOLINE

it is also post ganglionic

Question 2

What is the post ganglionc receptor ?

Answer 2

Postganglionic: muscarinic acetylcholine receptor (mAChR)

G-protein coupled receptors.

Question 3

What is the preganglionic receptor ?

Answer 3

Preganglionic: nicotinic acetylcholine receptor (nAChR)

Ligand-gated ion channels

Question 4

M1 receptors

What it is and what it does ?

Answer 4

Gq protein coupled: PLC → DAG & IP3 → ↑[Ca2+]

Located: CNS, GI tract, salivary & lachrymal glands

CNS excitation
Gastric secretion

Question 5

M2 receptors

Answer 5

Gi protein coupled: ↓AC → ↓cAMP → (↓[Ca2+]i)

Located: CNS, Heart

Cardiac inhibition
CNS inhibition (inc. tremor, hypothermia )

DECREASE HEART RATE

Question 5

M3 receptors

Answer 5

Gq protein coupled: PLC → DAG & IP3 → ↑[Ca2+]

Located: Exocrine glands: GI & salivary, smooth muscle, GI tract, eye, lungs, bladder, blood vessels

Gastric & salivary secretion, GI 	smooth muscle contraction, ocular 	accommodation, vasodilation, 	bronchoconstriction, bladder 	contraction

ITS IN A LOT OF PLACES !!