Synaptic transmision

Question 1

1 - Exlpain synaptic trasmsttion

Answer 1

1- Presynaptic action potential; entry of Na+ through voltage gated Na+ channels (VGNaC); depolarisation

2) Opening of voltage gated calcium channels; calcium flows into the synaptic terminal.

3) Calcium binds to vesicle docking proteins. Exocytosis: vesicle fuses with membrane and neurotransmitter secreted.

4) Neurotransmitter binds to postsynaptic receptors; ionotropic and metabotropic

5) Neurotransmitter is removed from the synaptic cleft by uptake and/or degradation by synaptic enzymes. Postsynaptic receptors close.

THEN BACK TO A NORMAL POTENTIAL WAITING FOR THE NEXT ONE.