The Cell Cycle Flashcards
What is mitosis?
Division into 2 genetically identical daughter cells and the parent cell
What is mieosis?
Division into 4 unique daughter cells with 1/2 the parent cells chromosomes
What happens in Gap 0 phase?
- Cells may go through apoptosis (cell death), differentiation of senescence
- Some cells may stay in this stage for a long time like neurones
What happens in Gap 1 phase?
- Cells grow and increase in size
- Transcriptions of genes and to make RNA occurs
- Organelles duplicate
- Biosynthesis, protein synthesis, including making the enzymes needed for DNA replication in S phase
What happens in S phase?
- When a cell reaches this point it is committed to the cell cycle
- DNA replicate
- When all chromosomes have been duplicated, each one consists of a pair of identical sister of chromatids
What happens in Gap 2 phase?
Cells grow and DNA mistakes are cheked for
What happens in M phase?
- Cell growth stops
- Nuclear division starts : PMAT
- Cytokinesis
Why is S phase rapid?
Because the exposed DNA base pairs are more susceptible to mutagenic agents, so its speed reduces the chances of spontaneous mutations happening
What happens in the checkpoint in M phase?
A chemical triggers the condensation stage in metaphase to ensure the cell is ready to complete mitosis
What happens in the checkpoint in Gap 1 ?
The p53 a gene for suppressing tumours and helps control G1
What happens in the checkpoint in Gap 2 ?
Special chemicals ensure the cell is ready for mitosis by stimulating proteins that will be involved in making chromosomes condense and in formation of the spindle.
What happens in prophase?
- The chromosomes condenses into chromatids
- The nuclear envelope and nucleolus disappear
- The centrioles go to different poles of the cell
- The centrioles use tubulin to grow spindle fibres to connect to the centromeres
What happens in metaphase?
The spindle fibres connect to the centromeres on the chromosomes and they go into the middle of the cell
What happens in anaphase?
- The spindle fibres breaks up the chromatids into chromosomes
- Motor proteins shorten and pull the chromosomes towards the opposing poles
What happens in telophase?
A nuclear envelope forms around the chromosomes at the 2 poles