thalamus and hypothalamus Flashcards

hypothalamus: recall the functions of the hypothalamus and interactions with the endocrine and autonomic systems and the brain controlling mood and behavior

1
Q

significance of thalamus and hypothalamus being very close to pituitary gland and brainstem

A

interacts with endocrine and autonomic systems in control of mood and behaviour

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2
Q

coronal section of human brain: location of hypothalamus in relation to third ventricle

A

walls and floor of third ventricle

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3
Q

what divides the hypothalamus into 2

A

third ventricle

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4
Q

what is the hypothalamus anatomically

A

collection of individual nuclei with distinct functions

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5
Q

where is hypothalamus in relation to optic chiasm, and which nuclei lies just above optic chiasm

A

just behind optic chiasm, just above is supraoptic nucleus

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6
Q

what type of connections are the majority of hypothalamic neurones involved in

A

ipsilateral (same side) connections with other nuclei

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7
Q

what 4 things is hypothalamus involved in

A

fighting, fleeing, feeding, mating

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8
Q

what does the hypothalamus have direct connections with

A

autonomic nervous system

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9
Q

what else does the hypothalamus have connections with

A

endocrine systems (e.g. hypothalamic-pituitary axis)

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10
Q

function of hypothalamus and relation to therapeutic treatments

A

control of behavious (e.g. feeding using lectin and other peptides; e.g. laser stimulation on hypothalamus on GLP1 peptide expression can be used in anti-obesity treatment)

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11
Q

where is the paraventricular nucleus located in the hypothalamus

A

very medial (lateral to and in middle of third ventricle)

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12
Q

where does paraventricular nucleus send projections to

A

autonomic nervous system (parvocellular - secretory that project to median eminence) and posterior pituitary gland (magnocellular - secretory that project to posterior pituitary)

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13
Q

evidence that paraventricular nucleus is involved in feeding behaviour

A

lesions cause hyperphagia and weight gain

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14
Q

paraventricular nucleus: what results in feeding

A

optogenetic stimulation of GABAergic LH neuron terminals from hypothalamic nuclei in paraventricular nucleus results in feeding

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15
Q

where is the suprachiasmatic nucleus located within the hypothalamus

A

anterior medial ventral, just above pituitary gland; very near to supraoptic nucleus

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16
Q

what is suprachiasmatic nucleus to do with

A

circadian rhythm

17
Q

functions of suprachiasmatic nucleus

A

connections to PVN so controls autonomic outflow; connections to pineal gland (melotonin) so controls sleep cycle

18
Q

suprachiasmatic nucleus location relative to optic chiasm

A

just ventral, medial to lateral geniculate nuclei

19
Q

example of cause of disrupted sleep cycle

A

lesions of suprachiasmatic nucleus (Parkinson’s spreads from base of brainstem up to suprachiasmatic nucleus, causing sleep disruption)