Tetracyclines

Question 1

Tetracycline (prototype) indications

Answer 1

Treatment of various infections caused by susceptible strains of bacteria; acne; when penicillin is contraindicated for eradication of susceptible organisms.

Question 2

Tretracycline actions

Answer 2

Inhibits protein synthesis in susceptible bacteria, preventing cell replication.

Question 3

Tetracycline route, onset, peak

Answer 3

Oral, varies, 2-4 h;

Topical, minimal absorption occurs

Question 4

Tetracycline adverse effects

Answer 4

Nausea, vomiting, diarrhea, glossitis, discoloring and inadequate calcification of primary teeth of fetus when used in pregnant women or of secondary teeth when used in children, bone marrow suppression, photosensitivity, superinfections, rash, local irritation with topical creams.