Lincosamides

Question 1

Lincosamides prototype

Answer 1

Clindamycin

Question 2

Clindamycin indications

Answer 2

Treatment of serious infections caused by susceptible strains of bacteria, including some anaerobes; useful in septicemia and chronic bone and joint infections.

Question 3

Clindamycin actions

Answer 3

Inhibits protein synthesis in susceptible bacteria, causing cell death.

Question 4

Clindamycin route, onset, peak, duration

Answer 4

Oral, varies, 1-2 h, 8-12 h;
IM, 20-30 min, 1-3 h, 8-12 h;
IV, immediate, minutes, 8-12 h;
Topical, minimal absorption

Question 5

Clindamycin T 1/2

Answer 5

2 to 3 hours; metabolized in the liver, excreted in the urine and feces.

Question 6

Clindamycin adverse effects

Answer 6

Nausea, vomiting, diarrhea, pseudomembranous colitis, bone marrow suppression.