Ketolides Flashcards
1
Q
Ketolides prototype
A
Telithromycin (Black Box warning for myasthenia gravis b/c it exacerbates respiratory problems).
2
Q
Telithromycin indications
A
Treatment of community-acquired pneumonia caused by susceptible bacteria.
3
Q
Telithromycin actions
A
Binds to bacterial ribosomes, altering protein function and leading to bacterial cell death.
4
Q
Telithromycin route, onset, peak
A
Oral, rapid 0.5-4 h
5
Q
Telithromycin T 1/2
A
10 hours; metabolized in the liver and excreted in the feces and urine.
6
Q
Telithromycin adverse effects
A
Headache, dizziness, nausea, vomiting, pseudomembranous colitis, superinfections.
