Macrolides Flashcards
1
Q
Macrolides prototype
A
Erythromycin (Macrolides are used mainly for endocarditis prophylaxis before dental procedures).
2
Q
Erythromycin indications
A
Treatment of respiratory, dermatological, urinary tract, and gastrointestinal infections caused by susceptible strains of bacteria.
3
Q
Erythromycin actions
A
Binds to cell membranes, causing a change in protein function and cell death; can be bacteriostatic or bactericidal.
4
Q
Erythromycin route
A
Oral, 1-2 h, 1-4 h;
IV, rapid, 1 h
5
Q
Erythromycin T 1/2
A
3 to 5 hours; metabolized int he liver, excreted in bile and urine.
6
Q
Erythromycin adverse effects
A
Abdominal cramping, vomiting, diarrhea, rash, superinfection, liver toxicity, risk for pseudomembranous colitis, potential for hearing loss.
