Cephalosporins

Question 1

Cephalosporins prototype

Answer 1

Cefaclor

Question 2

Cefaclor indications

Answer 2

Treatment of respiratory, dermatological, urinary tract, and middler ear infections caused by susceptible bacteria.

Question 3

Cefaclor actions

Answer 3

Inhibits the synthesis of bacterial cell walls, causing cell death in susceptible bacteria.

Question 4

Cefaclor route, peak, duration

Answer 4

Oral, 30-60 min, 8-10 h

Question 5

Cefaclor adverse effects

Answer 5

Nausea, vomiting, diarrhea, rash, superinfection, bone marrow depression, risk for pseudomembranous colitis.

Question 6

Cephalosporin facts

Answer 6

• Never given w/ Aminogylcosides, increases risk for nephrotoxicity.
• Used for preoperative prophylaxis 60 minutes prior to first cut to prevent surgical site infections. Vancomycin can also be used 120 minutes prior to first cut.