Test 4 Psychotherapeutic Agents Shi Flashcards
Therapeutic action of antipsychotic/ Neuroleptic drugs
Block dopamine receptors
Depress RAS
Anticholinerfic, antihistamine, and alpha andrenergic blocking effects
What are antipsychotic/ neuroleptic drugs indicated in?
Schizophrenia
Hyperactivity
Combatic behavior
Sevior behavioral problems in children
Contraindications of antipsychotics
Monitor QTc in at risk pt’s
Older adults with dimentia
Seizure disorders
Active alcohol use
Immunosuppression
Can cause death in older adults
Medical conditions that are exacerbated by anticholinergic effects
Adverse effects of antipsychotic drugs
CNS effects
CV
Respiratory effects
Drug interactions of antipsychotics
Alcohol
Anticholinergics
Ziprasidone/ Thioridazine with any drug that can prolong QTc interval
Examples of antipsychotics
Ziprasidone
Thioridazine
Respiradone
Chlopromazine
Bipolar Disorder Drugs
Lithium
Aripirazole
Cariprazine
Olanzapine
Quetiapine
Risperidone
What does lithium do?
Alters sodium transport in the nerve and muscle cells
Inhibits release of norepinierphrine and dopamine
Increases intraneuronal stores of norepiniphrine and dopamine slightly
What’s important regarding sodium when taking lithium?
Maintain normal sodium levels and have consistant sodium intake
Contraindicaitons of lithium
Significant renal or cardiac disaease
History of leukemia
Metabolic disorders
Dehydration
Pregn/lact
Fever infx
Adverse effects of Lithium
Less than 1.5: CNS problens, polyuria, beginning of gastric toxicity
1.5-2: Same reactions pplus ECG changes, sometimes brugada syndrome
2-2.5: Possible progression of CNS effects, CV effects, large output of dilute urine secondary to renal toxicity, fatalities secondary to pulmonary toxicity
>2.5: Complex multiorgan toxicity, significant risk of death
Drug interactions of lithium
Haloperidol
Neuromuscular blocking agents
Carbamazepine
Thiazide diuretic
Some NSAIDS
Actions of ADHD and Narcolepsy drugs
CNS stimulants
Increasing the release of catecholamines
Amphetamine stimulants block reuptake of norepinephrine and dopamine and also increase more of their release
When do ADHD and narcolepsy drugs peak?
2-4 hours
Contraindications of ADHD and Narcolepsy drugs
Marked anxiety
Agitation
Tenison
Glaucoma
Cardiac Disease
History of seizures
History of drug dependence
Adverse effects for ADHD and Narcolepsy drugs
CNS
GI
CV
Skin rashes
What are some ADHD drugs?
Amphetamine
Clonidine Hydrochloride
Guanfacine
Meth
What are some narcolepsy drugs?
Armodafinil
Methylphenidate
Modafinil
