Test 3 Lipid Lowering Agents shi Flashcards
What kinds of Lipid Lowering Agents are there?
Bile acid sequestrants
HmG-CoA reductase inhibitors
Cholesterol absorption inhibitors
Others
What drugs are bile acid sequestrants?
Cholestyramine
Colestipol
Colesevelam
What should you tell patients about the bile acid sequestrants?
They bind to other meds and reduce absorption of other meds
Need to be taken seperate w/ other meds
How do bile acid sequestrants work?
Bind with bile acid in intesitnes to form insoluble complex that is secreted in feces
What are bile sequestrants used for?
To reduce cholesterole in pt’s with hypercholesterolemia
Cholestyramine: treats pruritis associated with partial biliary obstruction
Contraindications of bile acid sequestrants
Complete biliary obstruction
Ileus
Bowel disease
Adverse effects of bile acid sequestrants
GI are big side ffects
Aggravation of hemorrhoids
Increased bleeding time
Vitamin A and E deficiencess
Muscle aches and pains
Interactions of bile acid sequestrants
Don’t take w other emds
Thiazide diuretics
Digoxin
Warfarin
Thyroid hormones
Hormonal contraceptives
corticosteroids
What drugs are HMG-CoA reductase inhibitors?
Atorvastatin
Fluvastatin
Lovastatin
Pitavastatin
Pravastatin
Rosuvastatin
Simvastatin
“Statins”
What do the HMG-CoA reductase inhbitors end in?
-statin
MOA of statins
Blocks HMG CoA from completing synthesis of cholesterol
Decreases LDL and slightly increases HDL
True or false: Statins can be cardioprotective?
TRUE
What can statins be used for?
Slow progression of ASCVD
Assist w prevention of MI and stroke
Treats increased cholesterol
Adverse effects of statins
GI
CNS
Hepatotoxicity
Rhabdomyolysis (breakdown of muscle which can cause renal failure)
Interactions of statins
NO GRAPEFRUIT JUICE
Contraindications of statins ?
Grapefruit juice and active liver disease
What’s an example of a cholesterol absorption inhibitor?
Exetimibe
* lowers LDL
How does Exetimibe work?
Works in brush border of smal intestine to decrease absorption of dietary cholesterol
Indications of Exetimibe
Reduces cholesterol
Adjunct to treat homozygous familial hypercholesterolemia
Lower sitosterol and campesterol levels in homozygous sitosterolemia
