Test 4 Opioid, Opioid Antagonists, and Antimigrane Shi

Question 1

Indications of opioids

Answer 1

Relief of severe acute or chronic pain
Analgesia during anesthesia

Question 2

Contraindications of opiods

Answer 2

Diarrhea caused by toxins (C.Diff, food posining, ecoli)
Presence of GI obstruction

Question 3

Adverse effects of opioids

Answer 3

Respiratory Depression
Ortho Hypo
GI
Neuro effects

Question 4

Drug interactions of Opioids

Answer 4

Barbiturate general anesthetics
Other CNS depressants
Tapentadol: SSRI, MAOI, TCA, St John’s Wort
Anticholinergic agents
Antihypertensive agents

Question 5

Opiod examples

Answer 5

Codeine
Alfentanil
Fentanyl
Hydrocodone
Levorphanol
Morphine

Question 6

Morphine mnemonic for side effects

Answer 6

M- Myosis
O- Out of it ; sedation
R- Resp Depression
P- Pneumonia (aspiration)
H- Hypotension
I- Infrequency (urinary retention or constipation)
N- Nausea
E- Emesis

Question 7

Narcotic Toxidrome signs

Answer 7

C- Coma
P- Pinpoint pupils
R- Resp depression
H- Hypoten
H- Hypothermia
H- Hyporeflexia

Question 8

What are ergot derivatives used for?

Answer 8

Migranes

Question 9

How do ergot derivatives work?

Answer 9

Cause constriction of cranial blood vessels and decrease pulsation of cranial arteries
Reduces hyperperfusion of basilar artery vascular bed

Question 10

Types of ergot derivatives

Answer 10

Dihydroergotamine
Ergotamine

Question 11

Triptans therapeutic action

Answer 11

Bind to selective seratonin receptor sites to cause vasoconstriction of cranial vessels

Question 12

Indications of triptans

Answer 12

Treatment of acute migraine
Sumatriptan also used for cluster headaches in adults

Question 13

True or false: Triptans are used for prevention of migraines ?

Answer 13

False

Question 14

Contraindications of triptans

Answer 14

Preg
CAD