Drugs Test 3 coagulation shi Flashcards
What kinds of drugs effect clot formaiton and resolution?
Antiplatelets
Anticoagulants
Thrombolytic agents
What drugs are antiplatelets?
Aspirin
Clopidogrel
Ticagrelor
Vorapaxar
Cilostazol
Anagrelide
How to antiplatelets work?
Ihibit platelet adhesion and aggregation by blocking receptor sites on the platelet membrane
Anagrelide: Blocks production of platelets in bone marrow
What are antiplatelets used for?
Maintenance of venous and arterial grafts
Preventds cerebrovascular occlusion
Treats peripheral artery disease
Contraindications of antiplatelets
Bleeding disorders or active bleeding
Recent surgery
Close head injury
Pregnancy and lactation
Adverse effects of antiplatelets
Bleeding
GI
Skin rash
Dizziness/ weakness
Which drugs are anticoagulants?
Warfarin
Heparin
Enoxaparin
Rivaroxaban
Apixaban
How to anticoagulants work?
Interfere with clotting cascade
Indications of anticoagulants
Warfarin: Maintains state of anticoagulation in which patient is susceptible to potentially dangerous clot formation
Dabigatran: Reduces risk of stroke and systemic embolism in patients with nonvalvular AF ; treats and prevents DVT
True or false: Heparin is generally safer for pregnant than warfarin ?
True
What lab value do you check for Heparin?
aPTT
Should be 60 seconds
What lab value do you check for Warfarin?
PT and INR
INR: 2-3
What’s the antidote for warfarin?
Vitamin K lol
What’s the antidote for heparin lmao?
Protamine sulfate
What is an example of a thrombolytic agent?
Alteplase
How do thrombolytic agents work?
Activate tissue plasminogen
Effective only if patient has plasminogen in the plasma
Used to dissolve clots that have formed
Indications of Alteplase?
Dissolution of formed thrombus
Adverse effects of Alteplase
Bleeding
Cardiac arrhythmias
Hypotension
Mental Status Chanfes
GI bleed
Hypersensitivity reactions
