Test 3 (Myscle Phys) Flashcards
Interferes with ability to produce AP’s
K+ accumulation
Due to the accumulation of lactate
Internal acidity
Leads to failure of excitation- contraction coupling
reduced SR calcium release
Caused by changes in the CNS rather than fatigue of the muscles themselves
Central fatigue
Utilized at onset on contractile activity, but limited by CP stores
Creatine phosphate
Takes place within muscle mitochondria if sufficient oxygen is present and is essential during long periods of activity
Cellular respiration
Supports anaerobic or high intensity exercise
Glycolysis
Provides sensory information about muscle length
Muscle spindle apparatus
Provide sensory information about tension exerted on tendons
Golgi tendon organs
What neurons are attached to muscle spindles?
Afferent neurons
Located on tendons near their junction with eh muscle
Golgi tendon organ
Monitor muscle tension
Golgi tendon organs
Inherited disease characterized by progressive deterioration of muscle tissue
Muscular dystrophy
Bacteria in food produces neurotoxin, which prevents the release of acetylcholine necessary for muscle contraction
Botulism
Neurodegenerative disease affecting various motor neurons which leads to loss of function leads to muscle weakness, atrophy, and spastic paralysis
ALS
Autoimmune disease in which antibodies are produced that attach to the acetylcholine receptors on the sarcolemma, this blocking or reducing the stimulatory effect of the neurotransmitter
Eye drooping????
Destruction of the neurons leads to paralysis of the skeletal muscle
Polio
Bacteria produces a neurotoxin that affects motor neurons in the spinal cord resulting in continuous stimulation and contraction of muscles
Tetanus
Disease caused by bacteria found in soil
Tetanus
Involuntary, regulated by autonomic system, striated
Cardiac muscle
Mass of cardiac muscle cells connected to each other via gap junction
Myocardium
Found in the walls of hollow organs and tubes with NO striations
Smooth muscles
What do long thin filaments attach to?
Dense bodies
What are the 3 types of smooth muscle filaments?
Thick myosin
Thin actin
Intermediate filaments
Consists of discrete units that function independently of one another (units must be separately stimulated)
Multiunit smooth muscle
Individual cells are electrically liked by gap junctions
Single-Unit smooth muscle
Excitation-Contraction coupling in smooth muscle
begins with rise in intracellular concentrations
calcium binds to calmodulin