TEST 2 Flashcards
prefered treatment for status epilepticus:
diazapam (benzodiazapine, or anything with “-azapam”
increased sensitivity to sound in one ear. A brain mri shows a mass in the posterior fossa. The _____ nerve on the ____ side is responsible for the ______
CN7 on the ipsilateral side is responsible for the hyperacusis (possible sign of Bell’s palsey if the damage is before the nerve comes off of the brain stem)
areflexic buzzword
guillain bare and lems both have “areflexic” as a buzzword
no tinnitus, no nausea, only when getting out of bed, 5-30s, nystagmus possibly early in disease (latent downbeat rotary nystagmus that reverses with upright position and fatigues with repeat testing) no other associated symptoms, 20 min 24 hours
bppv, meiner’s (is accompanied by tinnitus)
21 yr old female, cold sensation in foot for 4-5 days, slowly went away, had optic neuritis in left eye 2 years ago, one day eye became blurred and vision went out, then came back to 20/20, brisk reflexes and sustained clonus at right ankle, babinski on right, positive for oligoclonal bands
ms: 20-30 female, optic neuritis
2 weeks after recovering from illness (virus), 19 yr old complains of headache and neck stiffness. Has a fever and soon has deteriorated cognitive function. Becomes disoriented, lethargic, increasingly unresponsive, MRI shows damage to white matter of cerebral hemispheres
ADE Acute Demyelination encephalomyelitis
23 yr old woman awaken with bilateral leg weakness, numbness, urinary retention and impaired bowel control. She has had several episodes of blurred vision over the previous 2 years but always been attributed to idiopathic papillitis:
neuromyelitis optica
ms progressively gets worse, includes the brain or cerebellum, and has a progressive phase whereas nmo is just a bad situation that gets better
a 54 yr old alcoholic is brought to ed with profound agitation. Believed to have delirium tremens and is treated with thiamine and intravenous fluids. Serum sodium is noted to be markedly depressed and iv supplements are adjusted to rapidly correct this hyponatremia He becomes acutely quadriplegic and unresponsive and dies within 24 hours
central pontine myelinolysis
35 yr old woman with progressive numbness of right arm and difficulty seeing objects in the right visual field. Known to be hiv positive with homohemianopsia and decreased sensory perception in right upper extremity. MRI shows a demyelinating lesion of the left parietoocciptial area, and CSF PCR for JC virus is positive
PML, double stranded dna virus, haart therapy, always jc virus
27 yr old man develops recurrent episodes of involuntary movement. He is an iv drug user, with bacterial endocarditis. Involuntary movements are largely restricted to the right side, lost 40 lbs over 4 months, and has difficulty swallowing. CT shows large area of decreased density on left side of cerebrum, and eeg shows slowing over the left side of the head. Biopsy of lesion reveals oligodendrocytes with abnormally large nuclei and extensive demyelination with giant astrocytes in the lesion. Develops dementia, seizures, and bladder incontinence.
PML
a myelogram is performed on a patient with a subacute, worsening paraparesis. The MRI of the lumbar of the spinal cord shows a patchy enhancement at L4-5.
Acute Transvere Myelitis
Which of the following does NOT decrease with age? A. TST. B. Sleep stage N1 (men). C. Stage N3 (men). D. Stage R. E. REM latency
B. Stage N1 increases (men only in one study) or stays the same (women in one study).
Which of the following decreases with age?
A. Sleep latency.
B. Sleep efficiency.
B. Sleep efficiency decreases with age.
Which of the following is true about infant sleep?
A. Sleep is lighter and fragmented.
B. Stage 4 comprises about 50% of TST (total sleep time).
C. Sleep latency is increased.
D. A and C
B. Stage 4 sleep comprises about 50% of TST. In ADULTS, A and C are true.
Sleep deprivation results in which of the following?
A. Increased leptin.
B. Increased ghrelin.
C. Acute antibody response.
D. Stage R rebound before stage N3 rebound in recovery sleep.
B. Sleep deprivation increases ghrelin but decreases leptin and the acute antibody response. In recovery, sleep increased stage N3 occurs on the initial recovery night. Increased stage R may occur on subsequent nights.
Which of the following brain areas is active during NREM and REM sleep? A TMN (Tuberomamillary Nucleus) B LC (Locus Coeruleus) C DRN (Dorsal Raphe Nucleus) D VLPO (Ventrolateral Preoptic Nucleus)
1 D.
- Which of the following brain areas is active during REM sleep?
A LDT/PPT (Lateral Dorsal Tegmentum / Pedunculopontine Tegmentum)
B LC (Locus Coeruleus)
C DRN (Dorsal Raphe Nucleus)
D TMN (Tuberomamillary Nucleus)
2 A.
What is the neurotransmitter (neuromodulator) of VLPO (Ventrolateral Preoptic) neurons? A GABA, galanine. B 5HT. C HA. D NE.
4 A.
- Which of the following is NOT true about hypocretin (Hcrt) neurons?
A Stabilize wake-sleep transitions.
B Active during wake.
C Located in the lateral hypothalamus.
D Provide inhibitory input to the LC, DRN.
6 D. Stimulatory input to the LC and DRN.
7. What is the major transmitter/neuromodulator of neurons in the DRN? (Slide 23) A 5HT. B DA. C NE. D HA.
7 A (DRN is Serotonergic and 5HT is short for Serotonin)
8. Which of the following brain areas contains neurons active during BOTH wake and REM sleep? (probably don’t need to know this) A LC. B LDT/PPT. C DRN. D TMN.
8 B.
- During REM sleep, neurons in what area are responsible for hypotonia? (Slide 24)
A Subcoeruleus/sublateral dorsal tegmentum.
B LDT/PPT.
C LC.
D DRN.
E TMN.
9 A.
10. What neurotransmitter(s) is believed to mediate the inhibition of spinal motorneurons (by interneurons)? (Slide 24) A GABA/glycine. B Glutamate. C 5HT. D NE.
10 A.
1 Of the following, what is the best documented risk factor for OSA? A Cigarette smoking. B Alcohol consumption. C Postmenopausal status. D Obesity.
1 D. Obesity is the best documented risk factor of those listed.
2 Which of the following is NOT always true about patients with the OHS? (this question is a more difficult one) A Daytime PCO 2 ≥ 45 mm Hg. B BMI > 30 kg/m 2 . C Worsening PCO 2 and PO 2 with sleep. D AHI ≥ 5/hr.
2 D. Approximately 20% of OHS patients do not have OSA but simply have daytime hypoventilation that worsens during sleep.
3 Which of the following symptoms is less typical of pediatric patients with OSA?
A Diaphoresis and labored breathing during sleep.
B Hyperactivity or behavioral problems.
C Adenotonsillar hypertrophy of variable severity.
D Daytime sleepiness.
3 D. Daytime sleepiness is not a major complaint of pediatric OSA patients. However, sleepiness may not be recognized. Obese pediatric OSA patients are more likely to report sleepiness.
4 Which of the following is the ICSD-2 criterion for diagnosis of OSA in adults? (probably do not need to know, but she did reference the hours)
A (Apneas + hypopneas + RERAs)/hr = 5/hr.
B (Apneas + hypopneas + RERAs)/hr = 15/hr.
C (Apneas + hypopneas + RERAs)/hr = 5/hr + symptoms
D (Apneas + hypopneas + RERAs)/hr = 5/hr + symptoms OR (Apneas + hypopneas + RERAs)/hr ≥ 15/hr.
4 D. This option most completely describes the criteria for adult OSA.
6 Which of the following combinations has the highest probability of having OSA?
A Snoring, no witnessed apnea, hypertension.
B Snoring, daytime sleepiness, no witnessed apnea.
C Snoring, witnessed apnea, hypertension.
D No snoring, no witnessed apnea, daytime sleepiness.
6 C. Snoring, witnessed apnea, and hypertension were found to be major risk factors for the presence of OSA. Although daytime sleepiness is a cardinal symptom of OSA, many OSA patients do not report sleepiness.
1. A 25-year-old woman with daily RLS symptoms was started on pramipexole 0.125 mg and this was increased to 0.75 mg over several weeks. The patient feels that her RLS symptoms have improved but continue at a significant level. Her ferritin level is 100 µg/L. What do you recommend? A. Increase pramipexole to 1.0 mg. B. Switch to ropinirole 0.5 mg. C. Add oxycodone 5–10 mg. D. Add gabapentin 100 mg.
- C. The patient is on a fairly high dose of pramipexole for RLS treatment. She is tolerating the medication but significant symptoms persist. It is possible that an increase to 1 mg pramipexole will be effective but could increase the risk of augmentation. However, some would argue that A is also a correct answer. A change to a different DA is another option. The equivalent dose of ropinirole is around twice that of pramipexole. Ropinirole at a dose of 0.5 mg is NOT an equivalent dose compared with pramipexole of 0.75 mg. To avoid the risk of augmentation, most clinicians avoid high doses of DAs. The addition of oxycodone 5 to 10 mg is probably the most effective option. The addition of a BZRA or gabapentin could be tried in this situation. However, 100 mg of gabapentin is unlikely to be effective.