Test 1 - 71B Flashcards
Normal pH range:
7.35-7.45
Normal PCO2 range:
35-45 mm Hg
Normal HCO3 range:
22.26 mEg/L
Normal PO2 range:
80-100 mm Hg
Normal SO2 range:
95-100%
Normal Sodium range:
135-145 mEq/L
Normal Calcium range:
8.5-10.5 mEq/L
Ionized: 4.5-5.5 mg/dL
Normal Potassium range:
3.5-5.0 mEq/L
Normal Magnesium range:
1.5-2.5 mEq/L
Normal Chloride range:
95-105 mEq/L
Normal Phosphate range:
2.5-4.5 mg/dL
What are electrolytes?
Charged ions dissolved in body fluids.
Cations
positively charged ions
Anions
negatively charged ions
What do sodium levels maintain?
(Bones, blood clotting factors, beats) skeletal muscle contraction, cardiac contraction, and nerve impulse transmission
Hyponatremia
decreased sodium levels; net gain of water or loss of sodium-rich fluids that results in sodium levels less than 136 mEq/L
Hypernatremia
elevated sodium levels; serum sodium level greater than 145 mEq/L
What electrolytes are cations?
magnesium, potassium, sodium, calcium, and hydrogen
What electrolytes are anions?
phosphate, sulfate, chloride, bicarbonate, and proteinate
What are the symptoms of hyponatremia?
Depressed and Deflated: Seizures/coma, tachycardia with weak, thready pulse, respiratory arrest
What are sodium levels regulated by?
the kidneys
What type of solution is hyponatremia treated with?
lactated ringers or 0.9% isotonic saline
hypertonic sodium solution may be used to decrease cerebral edema
How is acute hyponatremia treated?
- administer hypertonic oral and IV fluids as prescribed.
- Administer 3% sodium chloride slowly
- Encourage high sodium foods
- monitor I&O and daily weight
- monitor vital signs and level of consciousness
What are the complications of acute hyponatremia?
coma, seizures, respiratory arrest
What are the symptoms of hypernatremia?
Big and Bloated: Rosy and red cheeks (santa), edema, low grade fever
polydipsia
(late signs: swollen dry tongue, N&V, increased muscle tone)
What type of fluid might be given to a patient with hypernatremia and water loss?
5% dextrose and 0.45% sodium chloride solution;
Isotonic non saline IV fluids (5% dextrose in water)
What is the major cation in the ECF?
Sodium (Na+-K+ pump)
What is the major cation in the ICF?
Potassium (Na+-K+ pump)
What does potassium play a vital role in?
cell metabolism, transmission of nerve impulses, functioning of cardiac, lung, and muscle tissues, and acid-base balance.
Potassium has a reciprocal action with what other electrolyte?
sodium
Hypokalemia
decreased potassium levels
What are the symptoms of hypokalemia?
Low and Slow:
Flat T waves, ST depression
Decreased reflexes, cramping muscles, paralyzed limbs
Constipation, hypoactive BS, paralytic ileum (Can lead to SBO)
What should be monitored in patients with hypokalemia?
Urine output
Shallow respirations/diminished breath sounds
Cardiac rhythm
Level of consciousness
What foods are high in potassium?
avocados, broccoli, dairy, dried fruit, cantaloupe, bananas, juices, melon, lean meats, milk. whole grains, citrus fruits
hyperkalemia
increased potassium levels
hyperkalemia increases the risk of what?
cardiac arrest
What are the symptoms of hyperkalemia?
Tight and Contracted (cramp)
Hyper heart - ST elevation, Vfib/Asystole, Hypotension, Bradycardia
Diarrhea/Hyperactive bowel sounds
Muscle paralysis/weakness, increased DTRs
What action do loop diuretics have on potassium?
increase the depletion of potassium in the renal system
What lab tests are associated with hyponatremia?
serum sodium (decreased) serum osmolarity (decreased)
What lab tests are associated with hypernatremia?
serum sodium (increased) serum osmolarity (increased) Urine sodium (decreased urine) Urine specific gravity and osmolarity (increased)
What lab tests are associated with hypokalemia?
serum potassium (decreased)
What lab tests are associated with hyperkalemia?
serum potassium (increased)
Hemoglobin and hematocrit (increased w/dehydration, decreased w/kidney failure)
BUN and creatinine (increased w/kidney failure)
Arterial blood gases (metabolic acidosis - pH less than with kidney failure)
hypocalcemia
decreased sodium levels
symptoms of hypocalcemia
Trosseus - arm twerk w/BP cuff
Chvostek sign - smile stroke cheek
Diarrhea, circumoral tingling
Weak bones, weak blood clotting, weak heart beating
hypercalcemia
increase in sodium levels
symptoms of hypercalcemia
Swollen and Slow (moans, groans, stones)
Constipation, bone pain, kidney stones, decreased DTRs
hypomagnesemia
decreased magnesium levels
symptoms of hypomagnesemia
Buck Wild
Vfib, tachycardia, ST depression, hyperreflexia
Nystagmus, Diarrhea
hypermagnesemia
increased magnesium levels
symptoms of hypermagnesemia
Calm and Quiet
Heart blocks, bradycardia, hypotension
Decreased DTRs, Low RR, hypoactive bowel sounds.
What foods contain high magnesium?
dark green vegetables, nuts, whole grains, seafood, peanut butter and cocoa.
symptoms of hypochloremia
diarrhea, vomit, sweating, fever
symptoms of hyperchloremia
N&V, swollen dry tongue, confusion
What electrolytes are dominant in the ECF?
Cl-, CA++, HCO3-, Na+
What electrolytes are dominant in the ICF?
K+, Mg++, PO4(3-)
What is the major anion in the ECF?
Cl- (Cl- follows Na+)
What is the major anion in the ICF?
PO4(3-) (needed to form ATP)
Which is more acidic? ECF or ICF?
ICF is more acidic because metabolism produces acids and metabolism takes place in the ICF.
What happens with decreased phosphate levels?
decreased phosphate PO4(3-) = decreased ATP = decreased enzyme activity which causes: Decreased O2 transport (hypoxia) Decreased WBC function (infection) Decreased metabolism (starvation) Decreased blood clotting (bleeding) "Refeeding Syndrome"
Normal sodium function is related to:
fluid regulation
“Sodium: CNS” -> mental status disorder
Normal potassium function is related to:
Resting membrane potential
“Kalium - Kardiac” -> arrhythmia
Normal calcium function is related to:
permeability of Na+ (excitability)
“ContrA exCitAbility”: decrease Ca/increase excitability (confusion, spasm, seizures); increase Ca/decrease excitability (fatigue, lethargy, constipation)
What other electrolytes does Mg++ affect?
the active transport of Na+ and K+
What are the Isotonic Fluid types?
0.9% Saline
5% Dextrose in Water (D5W)
5% Dextrose in 0.225% Saline
Lactated Ringers
Why are isotonic fluids used?
to increase ECF volume loss from: blood loss, dehydration (vomiting and diarrhea), surgery
What are the Hypotonic Fluid types?
- 45% Saline (1/2NS)
- 225% Saline (1/4NS)
- 33% Saline (1/3NS)
Why are hypotonic fluids used?
to hydrate the cell (to “dilute” plasma particularly in hypernatremia)
What conditions are hypotonic fluids used to treat?
DKA (diabetic ketoacidosis)
Hyperosmole hyperglycemia
What are the side effects of hypotonic fluids?
Hypovolemia
Cell Lysis
Depletes circulatory system fluid
When should hypotonic solutions NOT be used?
On patients w/intracranial pressure (shifts fluid to brain tissue), third spacing risk (edema), burns, trauma
What are Hypertonic Fluid types?
3% Saline 5% Saline 10% Dextrose in water 5% Dextrose in 0.9% Saline 5% Dextrose in 0.45% Saline 5% Dextrose in LR
What do hypertonic fluids treat?
Hyponatremia (pulls Na back into intravascular system) Cerebral edema (decreases swelling by removing fluid off brain) Severe hypovolemia (temporarily)
What can hypertonic fluids cause?
fluid overload with pulmonary edema
What are hypertonic fluids NOT used for?
renal or cardiac disease
What is potassium chloride (KCl) used for?
to treat or prevent low levels of potassium in the blood
What is sodium phosphate used for?
to empty the colon before a colonoscopy
What are the two major fluid body compartments?
intracellular and extracellular
which body compartment contains more water?
ICF contains 2/3 water
ECF contains 1/3 water
What is a comprehensive metabolic panel?
a blood test that measures glucose level, electrolyte and fluid balance, kidney function, and liver function
What is a basic metabolic panel (BMP)?
a blood test consisting of a set of seven or eight biochemical tests and is one of the most common lab tests ordered by the health care providers
What does the anion gap blood test check?
the levels of acid in your blood
What is the average amount of fluid lost per day?
2-3L
What is sensible fluid loss?
fluid loss that can be seen such as urine or sweat
What is insensible fluid loss?
fluid loss that is not visible such as skin, lungs, saliva, feces
What are the three types of ECF?
interstitial (fluid around/between cells
intravascular (plasma - fluid in blood vessels - rich in protein)
Trans-cellular (CSF, GI tract, peritoneum, pleural, synovial fluids, aqueous humor, etc)
What percentage of an infants total weight does body fluids account for?
80% (60% in ECF, 40% in ICF)
What percentage of an adults total weight does body fluids account for?
50-60%
What percentage of an obese person’s total weight does body fluids account for?
45-50%
What do antidiuretic hormones do?
reduces the excretion of water
What does angiotensin II do?
vasoconstrictor and stimulates aldosterone
What does Aldosterone do?
reduces excretion of sodium and water
What does Atrial natriuretic peptide do?
increases excretion of sodium and water
What does bicarbonate do?
major buffer in regulating pH in the ECF
What is the best way to determine the need for O2 therapy?
ABG and VBG analysis
also measure the balance of acids and bases in your blood
What does the ABG test measure?
O2, and carbon dioxide and acids in the blood
What does the VBG test measure?
carbon dioxide and acids in the blood
What is a VBG normal range?
35-45 mmHg
Hypoventilation
breathing at an abnormally slow rate, resulting in an increased amount of carbon dioxide in the blood.
hyperventilation
is rapid and deep breathing. … You breathe in oxygen and breathe out carbon dioxide. Excessive breathing creates a low level of carbon dioxide in your blood.
hypoxia
a condition in which the body or a region of the body is deprived of adequate oxygen supply at the tissue level. Hypoxia may be classified as either generalized, affecting the whole body, or local, affecting a region of the body.
hypoxemia
having low oxygen levels in your blood
What are the first signs of hypoxia?
anxiety, restlessness, and/or confusion
What are the late signs of hypoxia?
blue tint to the skin, cyanosis, clubbing of fingers
Respiratory failure:
PO2 less than 50 mmHg and PCO2 greater than 50 mmHg
What are the 5 conducting systems of the heart?
Sinoatrial (SA) node "pacemaker of the heart" Intra-atrial pathways Atrioventricular node Bundle of HIS Purkinje network
What is the job of the Sinoatrial (SA) node?
“pacemaker of the heart” - impulses are initiated at the SA node at an intrinsic rate of 60-100 cardiac action potentials per minute in an adult at rest.
What is the job of the Atrioventricualr node?
The AV node mediates impulses between the atria and the ventricles; delays impulse before transmitting to assist atrial emptying.
cardiac output
the amount of blood ejected from the left ventricle each minute
Stroke volume
the volume of blood ejected from the ventricles during systole
Preload
the amount of blood in the left ventricle at the end of diastole (end-diastolic volume)
afterload
the resistance to left ventricular ejection
surfactants
chemical produced in the lungs to maintain the surface tension of the alveoli and keep them from collapsing.
diffusion
the process for the exchange of respiratory gases in the alveoli of the lungs and the capillaries of the body tissues.
About how much oxygen is contained in dry atmospheric air?
21%
hypercapnia
a condition of abnormally elevated carbon dioxide (CO2) levels in the blood.
cyanosis
blue discoloration of the skin and mucous membranes
What are the major causes of hypoxemia?
- poor alveolar ventilation
2. decreased diffusion of oxygen from alveoli to pulmonary capillaries
Atmospheric pressure
760 mmHg
what is hypoxemia defined/diagnosed as?
PO2 of less than 60 mmHg or O2 saturation of less than 90%
prolonged vomiting or gastric suctioning can result in what?
metabolic alkalosis
ventilation
the process of moving gases into and out of the lungs
perfusion
the ability of the cardiovascular system to pump oxygenated blood to the tissues and return deoxygenated blood to the lungs.
Diffusion
exchange of respiratory gases in the alveoli and capillaries
hypovolemia
a decreased volume of circulating blood in the body.
Blood and tissue oxygenation is via the process of:
Ventilation
Perfusion
diffusion
Diffusion
movement of molecules from an area of higher concentration to one of lower concentration
Facilitated diffusion
addition of specific carrier molecules to aid/accelerate diffusion
Osmosis
movement of water from areas of lower concentration to higher concentration
active transport
molecules move from area of low to higher concentrations through the use of external ATP
Osmotic pressure
a tendency of water moving from one compartment into another
how is osmotic pressure measured?
osmolarity (mOsm/L) and osmolality (mOsm/kg)
how is osmolality determined?
by the number of dissolved particles, mainly Na, urea and glucose per kg of H2O
What is normal body osmolality?
275-295 mOsm/kg
What organ is mainly responsible for maintaining concentration of body fluids within normal range of osmolality?
kidneys
How do the kidneys maintain concentration of body fluids?
through changes in antidiuretic hormone (ADH), R-A-S systems, solutes/water filtrations, excretions, and secretion
First spacing
describes normal distribution of fluid in the body in both the intracellular and extracellular fluid compartments.
Second spacing
describes the excess accumulation of fluid in the interstitial spaces, which we also call edema.
Third spacing
occurs when fluid accumulates in areas that normally have no fluid or minimal amount of fluid, such as with ascites, and edema associated with burns. In extreme cases third spacing can cause a relative hypovolemia.
how much does 1L of water weigh?
2.2 lbs
what is the minimum output per hour necessary to maintain renal function?
30mL/h
How much of a average person’s body weight and total body water is contained in the ICF?
40% of body weight and 70% of total body water
How much of a average person’s body weight and total body water is contained in the ECF?
20% of total body weight and 30% of total body water
What are the three types of ECF?
interstitial - fluid around/between cells
Intravascular - (plasma) fluid in blood vessels (rich in proteins)
trans-cellular - CSF, GI tract, synovial fluids, etc.
How much of an infants total weight is body fluids?
80%
How much of an adults total weight is body fluids?
50-60%
How much of an obese persons total weight is body fluids?
45-50%
What is the concentration of hypertonic solutions compared to the ICF?
they have a higher concentration of particles (high osmolarity) than ICF
What is hypertonic solution used for?
to expand vascular volume
What is hypotonic solution used for?
to “dilute” plasma particularly in hypernatremia
treats cellular dehydration
Isotonic dehydration
H2O and electrolyte loss in equal amounts: diarrhea and vomiting
hypertonic dehydration
H2O loss is greater than electrolyte loss; excessive perspiration, diabetes insipidus
hypervolemia
fluid volume excess (FVE)
A solution that has HIGH osmolarity
hypertonic
A solution that has LOW osmolarity
hypotonic
A solution that has equal osmolarity as serum
isotonic