Teratogens Flashcards
Ace Inhibitors
Renal Damage
Alkylating agents
Absence of digits, multiple anomalies
Aminoglycosides
CN VIII toxicity
Carbamazepine
Neural tube defects, craniofacial defects, fingernail hypoplasia, developmental delay
DES
vaginal clear cell adenocarcinoma
congenital Mullerian anomalies
Folate antagonists
neural tube defects
Lithuim
Ebstein anomaly (atrialized right ventricle)
Methimazole
Aplasia cutis congenita
Phenytoin
Fetal hydantoin syndrome: microcephaly, dysmorphic craniofacial features, hypoplastic nails and sital phalanges, cardiac defects, intellectual diability
Tetracyclines
Discolored teeth
Thalidomide
Limb defects (flipper limbs)
Valproate
Inhibition of maternal folate absorption-> neural tube defects
Warfarin
Bone deformities, fetal hemorrhage, abortion, opthalmalogic abormailaties
Alcohol
FAS: birth defects and intellectual disability
Cocaine
Abnormal fetal growth and fetal addiction
placental abruption
Smoking
low birth weight
preterm labor
ADHD
IUGR
Iodine
congenital goiter or hypothyroidism (cretinism)
Maternal diabetes
caudal regression syndrome (anal atresia)
congenital heart defects
neural tube defects
Vitamin A
HIGH RISK
spontaneous abortions and birth defects
X-rays
microcephaly, intellectual disability
