Teratogens

Question 1

Ace Inhibitors

Answer 1

Renal Damage

Question 2

Alkylating agents

Answer 2

Absence of digits, multiple anomalies

Question 3

Aminoglycosides

Answer 3

CN VIII toxicity

Question 4

Carbamazepine

Answer 4

Neural tube defects, craniofacial defects, fingernail hypoplasia, developmental delay

Question 5

DES

Answer 5

vaginal clear cell adenocarcinoma

congenital Mullerian anomalies

Question 6

Folate antagonists

Answer 6

neural tube defects

Question 7

Lithuim

Answer 7

Ebstein anomaly (atrialized right ventricle)

Question 8

Methimazole

Answer 8

Aplasia cutis congenita

Question 9

Phenytoin

Answer 9

Fetal hydantoin syndrome: microcephaly, dysmorphic craniofacial features, hypoplastic nails and sital phalanges, cardiac defects, intellectual diability

Question 10

Tetracyclines

Answer 10

Discolored teeth

Question 11

Thalidomide

Answer 11

Limb defects (flipper limbs)

Question 12

Valproate

Answer 12

Inhibition of maternal folate absorption-> neural tube defects

Question 13

Warfarin

Answer 13

Bone deformities, fetal hemorrhage, abortion, opthalmalogic abormailaties

Question 14

Alcohol

Answer 14

FAS: birth defects and intellectual disability

Question 15

Cocaine

Answer 15

Abnormal fetal growth and fetal addiction

placental abruption

Question 16

Smoking

Answer 16

low birth weight
preterm labor
ADHD
IUGR

Question 17

Iodine

Answer 17

congenital goiter or hypothyroidism (cretinism)

Question 18

Maternal diabetes

Answer 18

caudal regression syndrome (anal atresia)
congenital heart defects
neural tube defects

Question 19

Vitamin A

Answer 19

HIGH RISK

spontaneous abortions and birth defects

Question 20

X-rays

Answer 20

microcephaly, intellectual disability