Protooncogenes/ Tumor Supressors Flashcards
1
Q
BCR-ABL
A
Oncogene
CML, ALL
Tyrosine kinase
2
Q
bcl-2
A
Oncogene
Follicular and undifferentiated lymphomas
Anti-apoptosis
3
Q
BRAF
A
Oncogene
Melanoma
Serine/Threonine kinase
4
Q
c-myc
A
Oncogene
Burkitt lymphoma
Transcription factor
5
Q
Her2 neu /c-erbB2
A
Oncogene
Breast and ovarian
Tyrosine kinase
6
Q
L-myc
A
oncogene
Lung tumor
7
Q
N-myc
A
oncogene
neuroblastoma
8
Q
ras
A
oncogene
colon cancer, lung cancer, prostate cancer
GTPase
9
Q
ret
A
oncogene
MEN2A and MEN2B
tyrosine kinase
10
Q
APC
A
TS
colorectal cancer
11
Q
BRCA1/2
A
TS
breast and ovarian cancer
12
Q
MEN1
A
TS
MEN type 1
13
Q
NF1
A
TS
Neurofibromatosis type 1
14
Q
NF2
A
TS
Neurofibromatois type 2
15
Q
p53
A
TS
most human cancers (Li-Fraumeni syndrome)
