Neuro 7 Flashcards

1
Q

Calculation for risk

A

number of diseased people/number of people at risk

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2
Q

Brain hemorrhage caused by fracture to the temporal bone that has a lucid interval

A

epidural (between bone and dura)

tear of middle meningeal artery

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3
Q

Brain hemorrhage that shows blood in basal cisterns on CT

A

subarachnoid hemorrhage

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4
Q

Drug used in opioid overdose

A

Naloxone

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5
Q

What opiate effects are mediated by the mu receptor

A
respiratory and cardiac depression
reduced GI motility
physical dependence
euphoria
sedation
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6
Q

sensorineural hearing loss
tinnitus
paralysis of facial muscles
loss of corneal reflex

A

compression of CNV, VII, and VIII by acoustic neuromma and cerebellopontine angle

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7
Q

Use of botulism toxin injection

A

focal dystonias, achalasia, and spasms

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8
Q

Synaptophysin

A

protein that can be stained for in tumors of neuronal origin (rare in adults)

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9
Q

Why does pentazocine cause withdrawl symptoms in patients who are addicted to opioids

A

partial agonist and weak antagonist activity at mu receptors

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10
Q

Waerhouse-Friderichsen syndrome

A

Complication of meningococcemia
may involve adrenal gland destruction
DIC
shock

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11
Q

genera sensation from the anterior 2/3 of the tongue

A

mandibular division of trigeminal

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12
Q

taste innervation from the anterior 2/3 of the tongue

A

chorda tymapni branch of facial nerve

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13
Q

Injury to visual pathways in the temporal lobe causes

A

contralateral superior quandrantanopia

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14
Q

myotonia

A

abnormally slow relaxation of muscles

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15
Q

myotonic muscular dystrophy

A

AD disorder
due to trinucleotide repeat on myotonia-protein kinase gene
Also- cataracts, frontal balding, gonadal atrophy

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16
Q

MOA of benzodiazepines

A

increase frequency of opening of CNS GABAa receptor-chloride channels
have anti-convulsant, anxiolytic, sedative-hypnotic, and muscle relaxant effects

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17
Q

How is zolpidem different than benzodiazepines

A

short acting/rapid onset hypnotic

lower risk of tolerance and dependence

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18
Q

Use of rifampin

A

chemoprophylaxis for meningococcal meningitis.

19
Q

Uses of valproic acid

A

anticonvulsant and mood stabalizer (prevents mania)

MOA: increases synthesis and decreases breakdown of GABA

20
Q

Three mood stabilizing agents

A

Lithium, valproic acid, and carbamazepine

21
Q

How do you diagnose tetanus toxicity

A

H&P

22
Q

Why can’t you take a MAOI and SSRI at the same time?

A

MAOIs irreversibly bind MAO, which degrades serotonin. If SSRI’s are started before more MAO can be generated, there will be extra serotonin around in the synapse -> serotonin syndrome

23
Q

Most common side effects of SSRIs

A

Sexual dysfunction

24
Q

List 4 TCAs

A

Imipramine, doxepin, amitryptyline, clomipramine

25
Q

AE of TCAs

A

Urinary retention
cardiac arrhythmias
seizures
orthostatic HoTN

26
Q

Most common cause of aseptic meningitis

A

Enterovirus

27
Q

fever, malaise, aseptic meningitis
then
severe myalgias, asymmetric polymyositis
unimmunized pt

A

polio

28
Q

CSF pattern in viral meningitis

A

glucose: normal
protein: increased
cells: lymphocytic pleocytosis

29
Q

neonatal intraventricular hemmorrhage into the lateral ventricles comes from what source

A

germinal matrix: vascularized sub ventricle area from which neurons and glial cells migrate out during development
happens in premies

30
Q

Primidone is broken down into

A

phenobarbiol and PEMA

all three compounds have anti-convulsant activity

31
Q

What muscle disorder is seen in patients with temporal arteritis

A

polymyalgia rheumatica

32
Q

Sporadic encephalitis with temporal lobe involvement

A

HSV-1

33
Q

MOA and AE of carbamazepine

A

blocks voltage gated sodium channels

causes bone marrow supression

34
Q

Two diseases that cause oligodendrocyte depletion

A

MS and progressive multifocal leukoencephaloptahy

35
Q

Cardiac use of atropine

A

bradycardia

36
Q

Pancoast tumor

A

lung tumor that compresses superior sympathetic cervical ganglion. Can also cause ipsilateral compressive brachial plexopathy

37
Q

MOA of entacapone

A

Also, tolcapone

COMT inhibitor. Prevents peripheral methylation of L-DOPA, increases the amount available to go to the brain

38
Q

AE of buproprion

A

agitation, insomnia, seizures

NOT sexual dysfunction

39
Q

What is contained in a Nisseria meningitis vaccine

A

immunogenic capsular polysaccharides. Induces production of anti-capsular antibodies

40
Q

What property of methodone makes it a good substitute for heroin

A

long half life-> surpresses withdrawal symptoms

41
Q

Cutaneous and subcutaneous neurofibromas are tumors of what cell type?

A

Schwann cells

42
Q

Abnormalities in first arch syndrome

A

malformation of mandible, maxilla, malleus, incus, sygoma, vomer, palate, and tempora bone
Associated with trigeminal nerve

43
Q

Which side effects opiates do not develop tolerance

A

miosis and constipation