TCA Cycle

Question 1

What is the main compound that enters the TCA cycle and what does it combine with and what does that form

Answer 1

Acetyl CoA+ OAA = Citrate

Question 2

Where is the PDC found and what does this reaction produce

Answer 2

mitochondrial matrix, 1 NADH per 3C pyruvate molecule

Question 3

What is a deficiency in PDC

Answer 3

Leigh’s disease

Question 4

What are the two main irreversible steps in the TCA cycle and what do they produce

Answer 4

alpha Ketoglutarate DH and isocitrate DH; both produce CO2 and NADH

Question 5

What pathways fill in the TCA cycle with intermediates

Answer 5

anaplerotic