Lipid absorption Flashcards

1
Q

List 3 isoprenoids

A

bile acids, bile salts and cholesterol

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2
Q

what cells release leptin

A

adipocytes

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3
Q

where are leptin receptors found

A

the hypothalamus

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4
Q

what does leptin do

A

signifies a satiated state, increase fat breakdown

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5
Q

what opposes leptin’s effects

A

grhelin

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6
Q

what are lingual lipase and gastric lipase optimized to digest

A

medium length lipids

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7
Q

what are bile salts derived from

A

cholesterol

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8
Q

what do bile salts do

A

emulsify fats, break up fat droplets

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9
Q

how do free FAs and MAG enter intestinal cells

A

passively

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10
Q

where do FAs and MAG from the intestinal lumen go once they enter the cell

A

they migrate to between the lipid bilayer of the ER

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11
Q

what digests TAGs in the small intestines

A

pancreatic lipase

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12
Q

what does pancreatic lipase break its product into

A

two free FAs and a 2-MAG

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13
Q

What all occurs in the lipid bilayer of the intestinal cell

A

FAs and MAG are activated by attachment to CoA and reformed into TAGs via TAG synthase

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14
Q

in the ER lumen, what is put into fat transportation bubbles (also, what are they called)

A

Chylomicrons contain FAs, CEs, and ApoB48

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15
Q

What is added to immature chylomicrons maturing them, and where does this occur

A

ApoCII and ApoE are added in the golgi

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16
Q

How do chylomicrons get into the general circulation

A

they are released basally into lacteals, travel to the thoracic duct, and from there enter the blood stream

17
Q

How do chylomicron’s contents enter into cells

A

FAs enter via ApoCII interacting with cellular lipoprotein lipase (LPL) which breaks done stored TAGs–> free FAs and absorbs them

18
Q

How are chylomicrons recycled

A

ApoE binds to LDL receptor related protein in the liver to absorb them