Post absorption fat metabolism

Question 1

What is cholesterol packed in from the liver

Answer 1

VLDLs

Question 2

Where does the liver get its cholesterol from

Answer 2

dietary cholesterol comes from recycled chylomicron remnants and it can make its own

Question 3

what proteins are added to VLDLs after they’ve been packed with cholesterol

Answer 3

ApoB100 and ApoE and C

Question 4

What mustt be removed from VLDLs prior to cholesterol release and how is this mediated

Answer 4

ApoCII interacts with LPL releasing TAGs, and hepatocyte TAG lipase removes more TAGs

Question 5

What is the progression from VLDL to the lipoprotein that only contains cholesterol

Answer 5

VLDL–> IDL –> LDL

Question 6

What is LDL’s function

Answer 6

carries cholesterol to cells where its ApoB100 protein allows it to be endcytosed

Question 7

How does atheroslerotic plaque form

Answer 7

when lots of LDL is in the blood, it gets oxidized and breaches the endothelial lining, causing macrophages to show up, become foam cells

Question 8

What is HDLs function

Answer 8

takes extra cholesterol from cells

Question 9

How do HDLs function

Answer 9

they use LCAT to transfer a free FA to cholesterol making it hydrophobic and causing it to enter the HDL

Question 10

What activates HDL’s LCAT

Answer 10

ApoA-I

Question 11

How are long FAs transported into mitochondria

Answer 11

carnitine binds FA and both are guided by carnitine acyl transferase I to carnitine acyl carnitine translocase

Question 12

In beta oxidation, what breaks FAs apart and what does this enzyme form

Answer 12

a dehydrogenase, FADH2 and NADH

Question 13

How are medium length FAs transported into the mitochondria

Answer 13

passively