Carbohydrate absorption Flashcards
what does alpha-amylase break down
alpha 1-4 loinkages
Where is alpha-amylase secreted
the mouth and pancrease
Which Glut receptor(s) is/are affected by insulin
Glut 4
Where is the insulin-affected Glut receptor expressed
fat, muscle and WBCs
How is glucose imported into the cell
facilitated diffusion
How is glucose kept inside the cell
phosphorylation by either hexokinase or gluckinase
where is glucokinase found
liver and pancreatic beta cells
where is hexokinase found
everywhere in the body
When is hexokinase active and what kind of Km does it have
at basal [glucose]. Low Km
When is glucokinase a active and what is its Km like
High [glucose] high Km
What inhibits hexokinase and what is this an example of
Glucose-6-phosphate, feedback inhibition
What is the cause of MODY
mutated glucokinase
Give the whole MODY cascade
Ineffective glucose kinase results in Glu escaping cell after being brought in, so low ATP. Ultimately, insulin isn’t released
What does cytoplasmic ATP do to transporters in the membrane
turns off K+ transporter, allows Ca2+ influx, and insulin efflux
