Biochemistry of cancer Flashcards
Where is the Rb gene located
chromosome 13
What is cancer predisposition
inheritance of one mutation in a protoncogene like Rb
How is Rb different from other protoncogenes
small number of mutations may result in cancer
How does pRb work
binds and inactivates E2F, a transcription factor, when unphosphorylated
How is pRb regulated
phosphorylation turns it off
How and when is p53 activated
phosphorylation due to cellular stress (damaged DNA)
How does p53 work
activates p21 when phosphorylated which inhibits cyclin/CDK complex. Also, activates apoptosis by activating ROSs
What kind of inheritance do oncogenes exhibit
dominant–only one needed to be mutated
When is Ras active
when bound to GTP
what does Ras do
it is a signal transducer that upregulates cell growth
What regulates Ras
GAPs
What do Fos and Jun do
increase cellular growth
What does the Myc gene product do
binds enhancers and recruits HATs
Give one example of Myc gene mutation
Burkitt’s lymphoma the result of Myc gene translocation
What chromosome is Myc found on
chromosome 8
